摘要
目的:考察芥子碱氯化盐对家兔离体肠平滑肌收缩功能的影响。方法:以家兔离体肠平滑肌收缩频率和张力为指标,采用Medlab-U/4C501H生物机能实验系统,考察不同浓度芥子碱氯化盐对家兔离体肠平滑肌收缩功能的影响。采用M受体阻断剂(阿托品)孵育肌条,观察芥子碱氯化盐在M受体阻断剂存在下对家兔肠管平滑肌收缩效应的变化。结果:各个实验浓度范围的芥子碱氯化盐对家兔离体肠平滑肌的收缩频率均无明显影响(P>0.05),各实验浓度芥子碱氯化盐能够显著提高家兔离体肠管的张力(P<0.01);M受体阻断剂阿托品对芥子碱氯化盐引起的肌条收缩有抑制作用,但抑制作用不完全。结论:芥子碱氯化盐对家兔离体肠管平滑肌具有兴奋作用,其兴奋肠管的作用与激动M受体有关。
Objective：To investigate the effect of sinapine chloride on the contractility of isolated ileum smooth muscle of rabbits .Methods：Use the contraction frequency and tension of muscle strips as indexes to investigate the effect of different doses of sinapine chloride on the contractility of isolated ileum smooth muscle , and the contraction information was recorded with Medlab -U/4 C501 H biological function experimental system .The muscle strips were incubated with M receptor blocker （ atropine ） to observe the effects of sinapine chloride con-tractile activity in the presence of atropine .Results：All doses of sinapine chloride had no obvious effect on the contraction frequency of isolated ileum smooth muscle strips （ P〉0 .05 ） .All doses of sinapine chloride could obviously increase the tension of muscle strips （ P〈0 .01 ） .M receptor blocker （ atropine ） could inhibit the contraction effect caused by Sinapine but the effect was incomplete .Conclusion：Sinapine chloride has an ex-citatory effect on the contractility of isolated ileum smooth muscle and the effect is related to the M receptor .
出处
《中医药信息》
2014年第4期4-7,共4页
Information on Traditional Chinese Medicine
基金
国家自然科学基金项目(No.31201336)
大连市科技计划项目(No.2012E15SF172)
关键词
芥子碱氯化盐
离体肠平滑肌
M受体
Sinapine chloride
Isolated ileum smooth muscle
M receptor
