摘要
目的探讨癌胚抗原(carcinoembryonic antigen,CEA)、神经元特异度烯醇化酶(neuron-specific enolase degree,NSE)、磷状上皮细胞癌抗原(squamous cell carcinoma antigen,SCC-Ag)与细胞角蛋白19片段(cytokeratin 19 fragment,CYFRA21-1)联合检查对肺癌的诊断价值。方法选取肺癌68例,同时选取良性肺疾病70例和健康体检人员90名作为对照组和健康组,分别应用全自动发光免疫分析仪开展血清检查,记录三组样本血清中的CEA、NSE、SCC-Ag与CYFRA21-1的含量,并进行比较分析。结果肺癌组的血清CEA、NSE、SCC-Ag与CYFRA21-1含量均显著高于其他两组,组间比较差异有统计学意义(P<0.05)。单一检测的特异性较高,与联合诊断比较无统计学差异,但联合诊断的灵敏度为80.9%,准确度为83.3%,均显著高于单一检测,差异有统计学意义(P<0.05)。结论血清CEA、NSE、SCC-Ag与CYFRA21-1的联合检查能有效提高肺癌诊断的敏感性和准确度,具有较好的诊断价值。
Objective To investigate the joint clinical value of carcinoembryonic antigen （CEA）, neuron-specific enolase de-gree （NSE）, squamous cell carcinoma antigen （SCC-Ag） and cytokeratin 19 fragment （CYFRA21-1） in diagnosis of lung cancer pa-tients.Methods 68 patients with lung cancer in this hospital from September 2012 to August 2013 were recruited , while 70 patients with benign lung disease and 90 healthy people as controls ,underwent automated immunoassay analyzer serological test .Two samples of serum CEA, NSE, SCC-Ag and content CYFRA21-1 were recorded to conduct comparative analysis .Results After testing, serum CEA in lung cancer group , NSE, SCC-Ag and CYFRA21-1 levels were significantly higher than those in the other two groups , the difference was statistically significant （P〈0.05） between groups .The CEA level in adenocarcinoma was significantly higher than that in the other two types;NSE level in small cell lung cancer was significantly higher than that in the other two types ;SCC-Ag and CY-FRA21-1 levels in squamous cell carcinoma were significantly higher than those in the other two types , the differences were statistically significant （P〈0.05）.High single detection specificity had no significant difference in the joint diagnosis , but the combined diagnos-tic sensitivity was 80.9%and the accuracy was 83.3%, significantly higher than those in a single test , the difference was statistically significant （P〈0.05 ）.Conclusions The serum lung cancer patients carry CEA , NSE, SCC-Ag and CYFRA21-1 joint diagnosis could effectively improve the sensitivity and accuracy of disease diagnosis , with the exact value of clinical application .
出处
《武警医学》
CAS
2014年第7期660-662,666,共4页
Medical Journal of the Chinese People's Armed Police Force
