期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

sFlt-1及PLGF的表达与早发型子痫前期的相关性 被引量：8

下载PDF
导出
摘要 目的:检测早发型子痫前期患者与正常晚期妊娠妇女血清及胎盘组织中可溶性血管内皮生长因子受体-1(sFlt-1)及胎盘生长因子(PLGF)的表达,并探讨二者在早发型子痫前期发病中的作用。方法:随机选取妊娠孕妇90例,分为三组。A组:正常晚期妊娠孕妇30例;B组:轻度早发型子痫前期孕妇30例;C组:重度早发型子痫前期孕妇30例。检测指标:(1)用酶联免疫吸附法(ELISA)检测三组孕妇血清中sFlt-1及PLGF的水平。(2)用免疫组化方法检测三组孕妇胎盘组织中sFlt-1及PLGF的表达。结果:(1)与A组比较,B组、C组血清及胎盘组织中sFlt-1水平均明显增高(P<0.05),PLGF水平均明显降低(P<0.05);且随早发型子痫前期的病情加重,sFlt-1水平亦随之增加,PLGF水平亦随之降低,各组两两比较差异有显著性(P<0.05)。(2)B组、C组患者血清及胎盘组织中sFlt-1水平分别与相应部位的PLGF水平呈负相关(r=-0.376,P<0.05;r=-0.425,P<0.05)。结论 :孕妇血清及胎盘组中sFlt-1、PLGF水平变化可能与早发型子痫前期孕妇发病及病情发展密切相关,且可作为监测患者病情变化的参考指标。
作者 杨丽萍 侯俊德 申自玮 冯海芹
机构地区 河北省邯郸市中心医院产一科 河北省邯郸市中心医院麻醉科
出处 《实用医学杂志》 CAS 北大核心 2014年第14期2263-2264,共2页 The Journal of Practical Medicine
关键词 早发型子痫前期 SFLT-1
分类号 R714.244 [医药卫生—妇产科学]
  • 相关文献

参考文献10

  • 1Shah DM. Preeclampsia new insights [J]. Curr Opin Nephrol Hypertens, 2007,16(3) :213-220.
  • 2Cudmore M J, Ramma W, Cai M, et al. Resveratml inhibits the release of soluble fins-like tyrosine kinase (sFlt-1) from human placental [J]. Am J Obstet Gynecol, 2012,206(3): 253 ,el0-15.
  • 3Bdolah Y, Karumanchi SA, Sachs BP. Recent advances in under-standing of preeclampsia [ J ]. Croat Med J, 2005,46 (5) : 728-736.
  • 4Redman CW, Sargent IL, Lares advance in understangding preeclampsia [J]. Science, 2005,308(5278) : 1592-1594.
  • 5李云,胡继芬.可溶性血管内皮生长因子受体1与子痫前期研究进展[J].国外医学（妇产科学分册）,2006,33(5):346-349. 被引量：9
  • 6Sehiettecatte J, Russcher H, Anckacert E, et al. Multicenter evaluation of the first automated Elecsys sFlt-1 and PIGF assays in normal pregnancies and preeclampsia [J]. Clin Biochem, 2010,43 ( 9 ) : 768 -770.
  • 7Verlohren S, Galindo A, Sehlembaeh D, et al. An automated method for the determination of the sFlit-1/PIGF ratio in the assessment of preeclampsia [J]. Am J Obstet Gynecol, 2010,202 (2):161.
  • 8Rana S, Powe CE, Salahuddin S, et al. Angiogenic factors and the risk of adverse outcomes in women with suspected preeclampsia [J ]. Circulation, 2012, 125 (7) : 911-919.
  • 9Kleinrouweler CE, Wiegerinck MM, Ris-Stalpers C, et al. Accuracy of circulating placental growth factor, vascular endothelial growth factor, soluble fins-like tyrosine kinase 1 ande soluble endoglin in the prediction of pre-eclampsia a systematic review and meta-analysis [J]. BJOG, 2012, 119(7) : 778-787.
  • 10杨丽萍,冯海芹,侯俊德,赵媛媛.可溶性endoslin及可溶性血管内皮生长因子受体-1的表达与早发型子痫前期的关系[J].实用医学杂志,2013,29(3):442-443. 被引量：16

二级参考文献25

  • 1雷玲,李力.子痫前期发病机制研究进展[J].国外医学（妇产科学分册）,2006,33(5):342-345. 被引量：11
  • 2李云,胡继芬.可溶性血管内皮生长因子受体1与子痫前期研究进展[J].国外医学（妇产科学分册）,2006,33(5):346-349. 被引量：9
  • 3Savvidou MD,Hingorani AD,Tsikas D,et al.Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia.Lancet,2003,361(9368):1511-1517
  • 4Buhimschi CS,Magloire L,Funai E,et al.Fractional excretion of angiogenic factors in women with severe preeclampsia.Obstet Gynecol,2006,107(5):1103-1113
  • 5Tsatsaris V,Goffin F,Munaut C,et al.Overexpression of the soluble vascular endothelial growth factor receptor in preeclamptic patients:pathophysiological consequences.J Clin Endocrinol Metab,2003,88(11):5555-5563
  • 6Thadhani R,Mutter WP,Wolf M,et al.First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia.J Clin Endocrinol Metab,2004,89(2):770-775
  • 7Ahmad S,Ahmed A.Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia.Circ Res,2004,95:884-891
  • 8Maynard SE,Min JY,Merchan J,et al.Excess placental soluble fmslike tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction,hypertension,and proteinuria in preeclampsia.J Clin Invest,2003,111 (5):649-658
  • 9Karumanchi SA,Bdolah Y.Hypoxia and sFlt-1 in preeclampsia:the"chicken-and-egg" question.Endocrinology,2004,145(11):4835-4837
  • 10Nagamatsu T,Fujii T,Kusumi M,et al.Cytotrophoblasts upregulate soluble fms-like tyrosine kinase-1 expression under reduced oxygen:an implication for the placental vascular development and the pathophysiology of preeclampsia.Endocrinology,2004,145 (11):4838-4845

共引文献23

同被引文献101

  • 1Patricia G,Zilma S,Silvia P,et al.Presymptomatic prediction of preeclampsia with angiogenic factors,in high risk pregnant women[J].Hypertens Pregnancy,2013,32(3):312-320.
  • 2Mutter WP,Karumanchi SA.Molecular mechanisms of preeclampsia[J].Microvasc Res,2008,75(1):1-8.
  • 3Bdolah Y,Sukhatme VP,Karumanchi SA.Angiogenic imbalance in the pathophysiology of preeclampsia:newer insights[J].Semin Nephrol,2004,24(6):548-556.
  • 4Kendall RL,Thomas KA.Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor[J].Proc Natl Acad Sci,1993,90(22):10705-10709.
  • 5Sela S,Itin A,Natason-Yaron S,et al.A novel human-specific soluble vascular endothelial growth factor receptor 1:cell-type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia[J].Circulation Research,2008,102(12):1566-1574.
  • 6Maynard SE,Min JY,Merchan J,et al.Excess placental soluble fms-like tyrosine kinase 1(sF lt1)may contribute to endothelial dysfunction,hypertension,and proteinuria in preeclampsia[J].J Clin Invest,2003,111(5):649-658.
  • 7Levine RJ,Maynard SE,Qian C,et al.Circulating angiogenic factors and the risk of preeclampsia[J].N Engl JMed,2004,350(7):672-683.
  • 8Jiang ZY,Zou YF,Ge ZP,et al.A role of sF lt-1 in oxidative stress and apoptosis in human and mouse preeclamptic trophoblasts[J].Biol Reprod,2015,93(3):73,1-7.
  • 9Agarwal I,Karumanchi SA.Preeclampsia and the antiangiogenic state[J].Pregnancy Hypertens,2011,1:17-21.
  • 10Jardim LL,Rios DRA,Perucci LO,et al.Is the imbalance between pro-angiogenic and anti-angiogenic factors associated with preeclampsia?[J].Clinica Chimica Acta,2015,447:34-38.

引证文献8

二级引证文献47

实用医学杂志
2014年 第14期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部