摘要
目的通过中药针剂三七总皂苷粉针、丹参粉针对急性脑梗死患者的临床疗效,验证中药针剂对急性脑梗死的神经保护作用机制。方法 80名急性脑梗死患者随机分成治疗组(三七总皂苷粉针0.4g/d),药物组(丹参粉针0.4g/d),于治疗前及治疗后2周测定血浆细胞间黏附分子-1、脂联素、高敏C-反应蛋白表达水平及神经功能缺损评分值。结果两组治疗后血脂联素含量均升高(P<0.05),细胞间黏附分子-1、高敏-C反应蛋白含量降低,治疗组明显优于对照组(P<0.05)。同时两组治疗后神经功能缺损评分值均有所下降,均以治疗组为优(P<0.05)。结论三七总皂苷粉针、丹参针对急性脑梗死有良好的脑保护作用。其作用机制在于通过降低局部脑组织细胞间黏附分子-1、高敏C-反应蛋白,升高脂联素的表达水平,从而减轻缺血性炎症反应,起到对缺血脑组织的神经保护作用。
Objective To investigate Neuroprotective effect of Traditional Chinese medicine injections on Acute cerebral infar~ tion. Methods Totally 80 patients with Acute cerebral infarction were divided into two groups, one group was treated with synthe1ical medicine and Danshen injection, another group was treated with synthetical medicine and Panax Notoginseng Saponins injec/ tion, the levels of Intercellular Adhesion Molecule - 1, High - sensitivity C - reactive protein and Adiponectin were measured be fore and after treatment, two weeks was a course of treatment. Results Intercellular Adhesion Molecule - 1, High - sensitivity q -reactive protein and the neurological functional deficit scales were descended, Adiponectin was elevated, the group with Pana Notoginseng Saponins injection better than the group with Danshen injection （ P 〈 0.01 ）. Conclusion Panax Notoginseng Sape nins and Danshen have good Neuroprotective effects. The theory was reduce inflammatory reaction and free radical damage, th group with Panax Notoginseng Saponins injection better than the group with Danshen injection.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2014年第7期1663-1664,共2页
Lishizhen Medicine and Materia Medica Research
基金
广西中医药管理局课题(No.GXKZ09-86)
关键词
三七总皂苷
细胞间黏附分子-1
脂联素
高敏C-反应蛋白
急性脑梗死
Total Notoginseng Saponin
Intercellular Adhesion Molecule - 1
High - sensitivity C - reactive protein
Ad-iponectin
Acute cerebral infarction
