摘要
纳米药物晶体技术是一种新颖的增加难溶性药物溶解度的药剂学途径,通过该技术制备的纳米药物晶体粒径小、载药量高,适用于多种给药途径,可显著提高药物溶解度和溶出速率,日益受到药剂工作者和研究人员的关注。通过查阅国内外文献,对纳米药物晶体的特点、増溶机理、制备方法、制备过程中使用的稳定剂以及市场应用等方面的研究情况进行了综述。
Drug nanocrystal technology is an innovative formulation approach to increase the solubility of poorly water-soluble drug.Drug nanocrystals arouse more and more attention from pharmaceutical workers and researchers because of their features such as small particle size,high drug loadings,increased saturation solubility and accelerated dissolution velocity.Based on the literature at home and abroad,the characteristics of drug nanocrystals,solubilization mechanism,preparation technologies,stabilizer used in its preparation and market applications are reviewed.
出处
《河北科技大学学报》
CAS
2014年第4期339-348,共10页
Journal of Hebei University of Science and Technology
基金
河北省自然科学基金(H2014208151)
河北省人力资源和社会保障厅留学人员科技活动择优资助项目
关键词
纳米药物晶体
难溶性药物
溶解度
溶出速率
制备方法
市场应用
drug nanocrystals
poorly soluble drug
solubility
dissolution velocity
preparation method
market application
