摘要
目的：研究基于补肾益冲丸的中西医结合优化方案治疗肾虚型排卵障碍性不孕的临床疗效及安全性。方法将360例肾虚型排卵障碍性不孕患者随机分为补肾益冲丸组（补肾益冲丸＋电针）、克罗米酚组[克罗米酚（clomiphene citrate，CC）＋人绒毛膜促性腺激素（human chorionic gon-adotrophin，HCG）]及补肾益冲丸优化治疗组（补肾益冲丸＋CC＋电针＋HCG）。三种治疗方案均设定3个月为1个疗程。纳入患者共接受1～4个疗程治疗后评价各方案疗效。结果补肾益冲丸优化治疗组的子宫内膜厚度、周期排卵率及妊娠率均显著高于克罗米酚组，但流产率显著低于克罗米酚组（P＜0．05）。子宫内膜厚度、最大卵泡直径及流产率在补肾益冲丸组与补肾益冲丸组优化治疗组比较，差异无统计学意义（P＞0．05），但补肾益冲丸优化治疗组的周期排卵率及妊娠率显著高于补肾益冲丸组（P＜0．05）。结论补肾益冲丸优化治疗方案可显著提高肾虚型排卵障碍性不孕患者的周期排卵率及妊娠率，并可改善子宫内膜容受性及降低流产率。
Objective Tostudytheclinicalefficacyandsafetyinthetreatmentofovulatorydys-functional infertility of kidney deficiency pattern with the optimization program of integrated Chinese and westernmedicinewithBushenyichongPills.Methods Threehundredandsixtycaseswererandomizedinto Bushenyichong Pills group[Pills ＋Electroacupuncture（EA）group],Clomiphen Citrate group[Clomiphen Citrate（CC）＋HCG group]and the optimization program group（Pills ＋CC＋EA＋HCG）.The treatment of 3 months made 1 session.The included patients received 1 to 4 sessions of treatment.The efficacy was as-sessedaftertreatmentwitheachprogram.Results Intheoptimizationprogramgroup,theendometrialthick-ness,cycle ovulation rate and pregnancy rate were all significantly higher than those in Clomiphene Citrate group,but the miscarriage rate was significantly lower than that in Clomiphene Citrate group（P〈0.05）.The differences in endometrial thickness,maximal follicular diameter and miscarriage rate were not significant be-tween Bushenyichong Pills group and the optimization program group（P〉0.05）.The cycle ovulation rate and pregnancy rate in the optimization program group were significantly higher than those in Bushenyichong Pillsgroup（P〈0.05）.Conclusion TheoptimizationprogramwithBushenyichongPillssignificantlyim-proves cycle ovulation rate and pregnancy rate,improves endometrial endurance and reduces miscarriage rate in the patients of ovulatory dysfunctional infertility of kidney deficiency pattern.
出处
《世界中西医结合杂志》
2014年第7期736-739,共4页
World Journal of Integrated Traditional and Western Medicine
基金
深圳市科技计划资助项目(No.201102197)
关键词
补肾益冲丸
肾虚
排卵障碍性不孕
临床研究
BushenyichongPills
KidneyDeficiency
OvulatoryDysfunctionalInfertility
ClinicalRe-search
