摘要
微小RNAs（microRNAs，miRNAs）是一类小分子非编码RNA，长度约921～25个核苷酸，参与调控人类约30％的基因，与许多生理及病理状态有关。目前，已在血清及血浆中检测到多种miRNAs，并且miRNAs的异常表达与肿瘤、心血管疾病及妊娠并发症等疾病密切相关。本文就循环miRNA与妊娠的研究进展做一综述。
MicroRNAs are a class of 21-25-nucleotides small, noncoding RNAs which regulate about 30% of the human genome. MiRNAs play an essential role in the physiology and pathology. Currently, a variety of miRNAs have been detected in the serum and plasma, and their deregulation has been associated with cancer, cardiovascular diseases, pregancy syndrome and other diseases. This review peovides a general overview of the current advances of circulating microRNAs and pregancy.
出处
《中国优生与遗传杂志》
2014年第8期9-11,共3页
Chinese Journal of Birth Health & Heredity
