摘要
目的:利用磁共振波谱(1H-MRS)分析研究青少年抑郁症患者前额叶的代谢改变。方法:收集年龄、性别及教育程度匹配的24例青少年抑郁症患者(抑郁症组)和23例健康青少年(对照组),应用多体素1H-MRS技术测量前额叶白质和灰质内N-乙酰天门冬氨酸盐(NAA)、胆碱复合物(Cho)、肌酸(Cr)等代谢物的水平。结果 :抑郁症组左背外侧前额叶白质NAA/Cr、Cho/Cr较对照组显著减低[NAA/Cr:1.67±0.32,t=3.126,P=0.004;Cho/Cr:1.28±0.30,t=2.362,P=0.024],抑郁症组右背外侧前额叶白质NAA/Cr较对照组显著减低[NAA/Cr:1.65±0.26,t=2.969,P=0.006],两组间双侧前扣带回灰质的代谢物无明显差异。结论:前额叶白质的代谢异常参与青少年抑郁症的发生过程,这些改变发生在疾病发生过程的早期。
Objective To explore the brain biochemical changes in the frontal lobe of adolescents with depression using proton magnetic resonance spectroscopy （1H-MRS）. Methods Twenty-four patients and twentythree healthy subjects matched for age, sex and education level were enrolled in the study. All the subjects underwent muhivoxel 1H MRS to measure the bilateral metabolic levels of N-acetylaspartate （NAA）, choline （Cho）, creatine （Cr） in the prefrontal lobes. Results The NAA/Cr and Cho/Cr ratios in the left dorsolateral prefrontal white matter of the depressive adolescents were significantly lower than those of the healthy subjects [NAA/Cr： 1.67 ± 0.32, t = 3.126, P= 0.004; Cho/Cr： 1.28 ± 0.30, t = 2.362, P= 0.024], and the ratios of NAA/Cr in the right dorsolateral prefrontal white matter of the depressive adolescents was also significantly lower than that of the healthy subjects [NAA/Cr： 1.65 ± 0.26, t = 2.969, P = 0.006]. There was no significant difference in the metabolic ratios in the bilateral anterior cingulate gray matter between the depressive adolescents and the healthy controls. Conclusions Biochemical abnormalities in prefrontal white matter are involved in the pathophysiology of depression. Importantly, these abnormalities are already present early in the course of the disorder.
出处
《实用医学杂志》
CAS
北大核心
2014年第15期2394-2397,共4页
The Journal of Practical Medicine
基金
国家自然科学基金项目(编号:81171303)
关键词
抑郁症
磁共振波谱分析
前额叶
青少年
Adolescent depression
Magnetic resonance spectrum
Prefrontal lobe
