摘要
目的:观察医用射线防护剂在头颈部恶性肿瘤放射性皮炎中的预防及治疗效果。方法:140例接受放射治疗的初治头颈部恶性肿瘤患者随机分为治疗组与对照组,各70例,采用三维适形调强放疗(IMRT)技术。治疗组在常规处理基础上使用医用射线防护剂,对照组仅行常规处理,评价医用射线防护剂在放射性皮炎中的预防及治疗效果。结果:所有患者均完成放疗计划,放射性皮炎发生率为100%,Ⅰ级发生率为72.14%,Ⅱ级及以上发生率为27.86%。治疗组Ⅱ级及以上放射性皮炎发生率为17.14%,对照组为38.57%(P<0.01)。治疗组患者放射性皮炎发生时间为(19.11±2.33)d,对照组为(15.54±1.87)d(P<0.05)。糖尿病患者的Ⅱ级及以上放射性皮炎发生率,治疗组为23.81%,对照组为62.50%(P<0.05);糖尿病患者出现放射性皮炎时间,治疗组为(16.01±1.63)d,对照组为(13.94±2.37)d(P<0.05)。结论:医用射线防护剂能明显延迟放射性皮炎发生时间,降低放射性皮炎的严重程度。
OBJECTIVE： To observe the prevention and therapeutic efficacy of medical anti-radiation protective agent on radio- dermatitis of head and neck cancer. METHODS ： 140 patients with head and neck cancer receiving radiotherapy were randomly di- vided into treatment group and control group, with 70 cases in each group. The intensity modulated radiation therapy （IMRT） was adopted in 2 groups, treatment group was additionally treated with medical anti-radiation protective agent during treatment, but con- trol group only received routine treatment. The preventive effect and therapeutic efficacy of medical anti-radiation protective agent were analyzed comparatively and evaluated. RESULTS： The experiment went successfully as plan, and all patients had suffered from radiodermatitis, among them the grade I was 72.14% and the grade II was 27.86% in which the treatment group was 17.14. %, and the control group was 38.57 % （P〈 0.01 ）. Moreover, the occurrence time of radiodermatitis was （ 19.11 ± 2.33） d in treatment group and （15.54 ± 1.87） d in control group （P〈0.05）. The incidence of grade II radiodermatitis or above in diabetes pa- tients was 23.81% in treatment group and 62.50% in control group （P〈0.05）. The occurrence time of radiodermatitis in diabetes patients was （16.01 ± 1.63）d in treatment group and （13.94 ± 2.37） d in control group （P〈0.05）. CONCLUSIONS： The medical anti-radiation protective agent can effectively delay the occurrence time and reduce the severity of radiodermatitis.
出处
《中国药房》
CAS
CSCD
2014年第30期2837-2839,共3页
China Pharmacy
关键词
医用射线防护剂
放射性皮炎
头颈部恶性肿瘤
放射防护
Medical anti-radiation protective agent
Radiodermatitis
Head and neck cancer
Radioprotection
