摘要
目的观察油茶皂苷(Sasanquasaponin,SQS)对小鼠的止咳、祛痰、平喘作用。方法止咳实验采用小鼠浓氨水引咳法和豚鼠枸橼酸引咳法,祛痰实验采用小鼠气管段酚红法和蛙上腭食道纤毛运动试验,平喘实验采用豚鼠喷雾致喘法和离体气管平滑肌螺旋条收缩实验。结果SQS(300、150、75mg·kg-1)和SQS(200、100、50mg·kg-1)分别可延长氨水引起小鼠与枸橼酸引起豚鼠的咳嗽潜伏期,高剂量组分别可减少两者的咳嗽次数;SQS(300、150、75mg·kg-1)均能增加小鼠气管酚红排泄量,SQS(终浓度16.0×10-4、8×10-4、4×10-4g·mL-1)能增加蛙食道纤毛运动速度;SQS(200、100、50mg·kg-1)无延长豚鼠气管痉挛所引起的哮喘潜伏期作用,SQS(终浓度为8.0×10-4、4.0×10-4、2.0×10-4g·mL-1)无抑制豚鼠离体气管平滑肌螺旋条收缩作用。结论 SQS具有良好的镇咳、祛痰作用,但平喘作用不明显。
OBJECTIVE To study the antitussive, expectorant and anti-asthmatic effects of sasanquasaponin （SQS）. METHODS The effect of antitussive was observed by ammonia water in mice and acid citric in guinea pig. The effect of expectorant was observed by determine the excreting phenol red from mice trachea and the ciliary movement in the frog＇s esophagus. The effect of Anti-asthmatic effect was observed by Spray with the mixture of histamine phosphate and acecolex and relax the vitro trachea both in the guinea pigs. RESULTS SQS（300,150,75mg · kg^-1）and SQS（200,100、50mg · kg^-1） can prolonged the cough latent period of mice and guinea pig,The frequency of Cough was decreased both in the two high groups. SQS（300,150,75mg · kg^-1） promoted phenolsulfonphthalein excretion. SQS（ 16.0 × 10 -4,8 × 10 -4,4 × 10-4g · mL-1 ） increase the speed of the ciliary movement in the frog＇s esophagus. SQS（200,100,50mg · kg^- 1 ） can not relax the vitro trachea of guinea pigs. SQS（ 8.0 × 10 -4,4. 0 × 10-4,2. 0 × 10-4g · mL^-1） can not inhibit the isolated tracheal smooth muscle strips contraction of guinea pigs. CONCLUSION SQS has significant effects on relieving cough and eliminating phlegm, without the effect of lessening asthma.
出处
《海峡药学》
2014年第7期52-55,共4页
Strait Pharmaceutical Journal
基金
福建省卫生厅青年科研基金项目(编号2007-1-19)
关键词
油茶皂苷
止咳
祛痰
平喘
SQS
Antitussive
Expectorant
Anti-asthmatic
