摘要
目的:观察藏医佐木阿汤及放血疗法对高原红细胞增多症(H A P C)模型大鼠血常规中红细胞(RBC)、血红蛋白(Hb)和红细胞压积(HCT)及血清促红细胞生成素(EPO)的影响。方法:选用雄性Wistar大鼠56只,随机分为平原对照组、高原模型组、药物组、放血组、药物加放血组。除平原对照组外,余组均饲养于拉萨以建立HAPC模型。饲养3个月后分别进行佐木阿汤灌胃和放血干预,干预3个月后取血进行血常规及EPO检测。结果:高原模型组大鼠RBC、Hb、HCT、EPO含量均较平原对照组升高(P<0.05);与高原模型组比较,药物组、放血组、药物加放血组干预后以上生化指标均降低,且药物组和药物加放血组效果更好(P<0.05),放血组仅对于RBC、EPO含量的影响具有统计学意义(P<0.05)。干预三组间比较均没有统计学意义。结论:藏医佐木阿汤与放血疗法对于HAPC的防治有效果。
Objective： To observe the effects of traditional Tibetan medicine Zuomua Decoction and blood-letting therapy on red blood cells （RBC）, hemoglobin （Hb）, hematocrit （HCT） and erythropoietin （EPO） of high altitude polycythemia （HAPC） rats. Methods： 56 male Wistar rats were randomly divided into the normal control group, model control group, Zuomua Decoction group, blood-letting therapy group and Zuomua Decoction combined with blood-letting therapy group. All groups were raised in Lhasa to establish HAPC model, except for the normal control group. After raising 3 months, Zuomua Decoction gavage and blood-letting therapy were carried on corresponding groups for 3 months. Then the blood of all groups was collected to detect the routine blood test and EPO. Results： The RBC, Hb, HCT and EPO in model control group were higher than those in normal control group （P〈0.05）. The above biochemical indicators in Zuomua Decoction group, blood-letting therapy group, Zuomua Decoction combined with blood-letting therapy group were lower than those in model control group, and the effects of Zuomua Decoction group and Zuomua Decoction combined with blood-letting therapy group were better （P〈0.05）. There was a statistical significance on the content of RBC and EPO in blood-letting therapy group （P〈0.05）. There was no statistical significance among 3 treatment groups. Conclusion： Zuomua Decoction and blood-letting therapy had effect on the prevention and treatment of HAPC.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2014年第8期2461-2463,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家重点基础研究发展计划(973计划)前期研究专项(No.2008CB517409)
国家自然科学基金(No.81260567)~~
