摘要
目的:探讨恶性肿瘤患者发生血液感染死亡的危险因素,以期降低死亡率,提高患者生活质量。方法:回顾性分析2011-01-01-2013-04-01河北联合大学附属医院重症医学科175例发生血液感染恶性肿瘤患者的临床资料,对其中23例死亡患者分别从性别、年龄、基础疾病、临床表现、实验室检查和影像学检查,以及侵袭性操作、是否存在脏器功能衰竭、人工呼吸机、药物治疗、APACHEⅡ评分、肾功能不全和凝血功能障碍等方面进行危险因素分析。结果:175例发生血液感染恶性肿瘤患者死亡23例,发生率为13.14%,其中年龄≥60岁(P=0.024)、脏器功能衰竭数目≥2个(P=0.024)、肾功能不全(P=0.019)、APACHEⅡ评分≥50(P=0.012)、凝血功能障碍(P=0.031)、有创操作(P=0.029)、感染性休克(P=0.035)和细菌种类≥3种(P=0.041)是恶性肿瘤患者血液感染死亡的单危险因素,也是独立危险因素。恶性肿瘤患者血液感染死亡发生与性别、基础疾病和放化疗无关,P>0.05。结论:恶性肿瘤患者血液感染死亡的危险因素为脏器功能衰竭数目≥2个、肾功能不全、APACHEⅡ评分≥50、凝血功能障碍、有创操作、感染性休克和细菌种类。
OBJECTIVE： To study the risk factors of death in patients with malignant tumor blood infection,in order to improve the clinical treatment and patien＇s life quality. METHODS： A retrospective analysis was performed for risk factors from 1st January 2011 to 1st April 2013 in 175 ICU stayed malignant tumor patients with blood infection in Hebei United University Affiliated Hospital,among them 23 cases died of blood infection and the risk factors such as gender, age, primary disease,clinical demonstration,lab tests, treatment procedures and function of the organs especially renal failure and hematological dysfunction as well as APACHE Ⅱ score ect. were analyzed. RESULTS： Twenty-three cases died in 175 patients with malignant tumor because of blood infection and the incidence was 13.14%,in which age 60 years or older （P= 0. 024）, multi-organ dysfunction（P= 0. 024）, renal insufficiency（P = 0. 019）, APACHE II score 50 or more （P = 0. 012） ,coagulation dysfunction（P= 0. 031） ,invasive operation（P=0. 029） ,septic shock（P=0. 035） ,bacterial species （or three） （P= 0. 041）were independent risk factors of blood infection. It had no relationships with sex, based diseases and radiation and chemotherapy（P〉0.05）. CONCLUSION： Multi-organ dysfunction, renal insufficiency, APACHE Ⅱ score 50 or more, coagulation dysfunction,invasive operation, septic shock and bacterial species are risk factors of blood infection of malignant tumor patients.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2014年第18期1405-1407,共3页
Chinese Journal of Cancer Prevention and Treatment
关键词
恶性肿瘤
血液感染
死亡
危险因素
malignant tumor
blood infection
death
risk factors
