摘要
目的观察2型糖尿病肾病(DN)患者血清单核细胞趋化蛋白-1(MCP-1)、核因子-κB(NF-κB)表达水平的变化,并探讨其临床意义。方法 76例2型DN患者根据尿白蛋白/尿肌酐(UAlb/UCR)分为早期DN组(n=27例)、临床DN组(n=25例)和晚期DN组(n=24例),检测3组血清MCP-1、NF-κB、血清肌酐(SCr)、尿素氮(BUN)、尿蛋白排泄率(UAER)表达水平,同期选择28例单纯2型糖尿病患者及30例门诊正常体检者作为对照组。结果各组在性别、年龄、腰臀比、身体质量指数(BMI)等各方面比较无显著差异性(P>0.05);各组DN患者血清SCr、BUN、UAER、MCP-1、NF-κB表达水平均明显高于对照组和单纯糖尿病组(P<0.05),且随着病情程度加重而显著性升高(P<0.05);而对照组与单纯糖尿病组比较无显著差异性(P>0.05);血清MCP-1和NF-κB表达水平分别与血清SCr、BUN、UAER表达水平呈显著正相关性关系(P<0.05)。结论 NF-κB和MCP-1表达水平升高均参与了DN发生、发展过程,阻断NF-κB信号转导途径,进而下调MCP-1表达水平可明显延缓DN的发生、发展过程。
Objective To observe the changes of monocyte chemoattractant protein-1 （ MCP-1 ） and nuclear-transcription factor-κB （ NF- κB） of patients with type 2 diabetic nephropathy （DN） , and the significance was explored. Methods According to the level of UAlb/UCR, 76 patients with type 2 diabetic nephropathy were divided into early DN group（ n = 27 ）, clinical DN group（ n = 25 ） and advanced DN（ n = 24）. The expression level of MCP-1 and NF-κB, serum creatinine（SCr）, blood urea nitrogen（BUN） and urinary albumin excretion rate （UAER） of the 3 groups were detected, meanwhile the indicators of 28 patients with type 2 diabetes and 30 normal controls were as control groups. Results There was no significant difference in gender, age, waist-hip ratio and BMI of 3 groups （P 〉 0.05）. The expression levels of SCr, BUN, UAER, MCP-1, NF-κB of all DN group were higher than those of other groups, and were significant higher along with the serious degree of disease （ P 〈 0.05 ）. There was no significant difference between type 2 diabetes group and control group （ P 〉 0.05 ）. There was a positive correlation between the expression level of MCP-1 and NF-κB and the expression level of SCr, BUN and UAER（ P 〈 0.05 ）. Conclusion NF-κB and MCP-1 express higher in DN can decrease MCP-1 expression by targeting NF-κB signaling pathways.
出处
《局解手术学杂志》
2014年第4期398-400,共3页
Journal of Regional Anatomy and Operative Surgery
关键词
糖尿病肾病
单核细胞趋化蛋白-1
核因子-ΚB
diabetic nephropathy
monocyte chemoattractant protein-1
nuclear-transcription factor-κB
