摘要
目的调查血液感染人苍白杆菌的临床分布及耐药性,为抗菌药物的使用及感染的控制提供流行病学资料。方法回顾性分析广东省深圳市中医院及四川省内江市第一人民医院2011年1月~2013年12月住院及门诊就诊患者血液培养分离的人苍白杆菌的临床分布及对12种抗菌药物的耐药情况。结果分离出人苍白杆菌231株,主要集中在感染科、重症监护科、肿瘤科等;对哌拉西林、氨曲南、头孢唑啉、氨苄西林-舒巴坦、哌拉西林-他唑巴坦、头孢噻肟耐药率高,耐药率〉90%;对头孢吡肟、厄他培南、亚胺培南、庆大霉素、环丙沙星、美罗培南敏感性较好,耐药率〈10%。随时间的推移,其耐药率有逐年增高趋势。结论人苍白杆菌已成为血液感染的重要病原菌之一;持续、准确地监测其流行趋势及耐药情况对该菌感染的防治具有重要意义。
Objective To explore the clinical distribution and antibiotic resistance of Ochrobactrum anthropi,direct the use of antibiotics and provide data of prevalence for Ochrobactrum anthropi infection.Methods We retrospectively analyzed the distribution of Ochrobactrum anthropi and antibiotic resistance to 12 antibiotics isolated from inpatients and out-patients in Shenzhen Hospital of Traditional Chinese Medicine and the First People＇s Hospital of Neijiang between January 2011 and December 2013.Results Two hundred and thirty one strains of Ochrobactrum anthropi were isolated from patients with septemia,mainly hospitalized in the Department of Infectious Diseases,the Intensive Care Unit,and the Department of Oncology.The drug resistance rate to piperacillin,aztreonam,cephazolin,ampicillin/sulbactam,piperacillin/tazobactam,and cefotaxime was up to 90%,while expressed a high sensitivity to cefepime,ertapenem,imipenem,gentamicin,ciprofloxacin and meropenem.The resistance rate of the antibiotics demonstrated an increase with time.Conclusion Ochrobactrum anthropi plays a role in patients with septemia.Accurately and persistently monitoring the characteristics of Ochrobactrum anthropi infection and antibiotic resistance can make a great difference in preventing and controlling the infection of Ochrobactrum anthropi.
出处
《中南药学》
CAS
2014年第7期714-716,共3页
Central South Pharmacy
关键词
人苍白杆菌
血流感染
耐药性
革兰阴性菌
Ochrobactrum anthropi
blood stream infection
antibiotic resistance
gram-negative bacterial infection
