摘要
目的：探讨2009年1月-2013年12月新疆维吾尔自治区人乳头瘤病毒（HPV）在不同宫颈病变中的基因型分布情况及其临床意义。方法：选取2009年1月-2013年12月自愿参与宫颈癌筛查的11256例妇女为研究对象，所有妇女均行液基细胞学（LCT）检查，同时采用导流杂交法测定宫颈细胞HPVDNA，并对高危型HPV（HR—HPV）进行基因分型，同时对HR—HPV患者行阴道镜宫颈活体组织学检查（活检）。结果：经LCT检查宫颈正常6896例，经阴道镜活检确诊为低危病变（LSIL）2125例，确诊为高危病变（HSIL）1779例，浸润性宫颈癌（ICC）456例，各组HPV总阳性率分别为1．48％、21．32％、53．74％、88．16％。HR—HPV中检出构成比最高前5位为HPV-51（30．82％）、16（23．56％）、35（18．00％）、18（10．65％）、52（7．26％），其中正常组分别为20．00％、10．00％、10．00％、5．00％、10．00％，LSIL组分别为46．43％、21．43％、16．07％、2．68％、0．89％，HSIL组分别为25．38％、20．93％、19．38％、13．38％、10．63％，ICC组分别为35．55％、29．48％、16．76％、8．96％、3．47％。结论：新疆维吾尔自治区妇女HPV感染近年呈上升趋势，HPV检出率随宫颈病变加重而显著升高，HPV-16／18是最常见的HR—HPV类型。临床通过对HR—HPVDNA类型进行检测将有助于宫颈癌早期诊断，具有重要的临床意义。
Objective： To explore the distributions and clinical signifieanees of human papillomavirus （HPV） genotypes in differ- ent cervical lesions in Xinjiang Uygur Autonomous Region from January 2009 to December 2013. Methods： A total of 11 256 women receiving cervical cancer screening voluntarily from January 2009 to December 2013 were selected as study objects, liquid -based cytology test （LCT） was performed; flow -through hybridization method was used to detect HPV DNA in cervical cells, and genotyping was conducted among high risk HPV （HR - HPV） ; cervical colposcopic biopsy was carried out in patients with HR - HPV. Results： After LCT, 6 896： women were found with normal cervix; after colposcopic biopsy, 2 125 women were diagnosed as low -grade squamousjntraepithelial lesion （ LSIL）, 1 779 women were diagnosed as high - grade squamous intraepithelial lesion （ HSIL）, 456 women were diagnosed as-invasive cervical cancer （ICC）, the total positive rates of HPV in the four groups were 1.48%, 21.32%, 53.74% and 88.16% ,＇respectively. The top five genotypes among HR - HPV were HPV 51 （30. 82% ）, HPV 16 （23.56%）, HPV 35 （ 18.00% ）, HPV 18 （10. 65% ） and HPV 52 （7.26%）, respectively; the proportions of HPV 51, HPV 16, HPV 35, HPV 18 andHPV 52 in normal Cervix group; LSIL group, HSIL group and ICC group were 20. 00% , 10. 00% , 10. 00% , 5.00% , 10. 00% ; ;46.43% , 21.43% , 16. 07% , 2. 68%, 0, 89% ：;. 25.38%：., 20. 93%, 19.38%, 13.38%, 10. 63% ; 35.55%, 29.48%, 16. 76%, 8. 96%, 3.47%., respectively. Conclusion： HPV infection rate shows an increasing trend among the women in Xinjiang Uygnr Autonomous Region, HPV detection rate incereases significantly with aggrava-tion of cervical lesions, HPV -16/18 are the most common HR-HPV genotypes. HR- HPV DNA detection is helpful to early diagnosis of cervical cancer, which has important clinical significance.
出处
《中国妇幼保健》
CAS
北大核心
2014年第23期3721-3724,共4页
Maternal and Child Health Care of China
基金
新疆医科大学科研创新基金项目〔XJC2013125〕
关键词
新疆维吾尔自治区
人乳头瘤病毒
宫颈病变
宫颈癌
Xinjiang Uygnr Autonomous Region
Human papillomavirus
Cervical lesion
Cervical cancer
