摘要
目的了解煤矿矿区成人社区获得性肺炎（CAP）非典型病原体分布及影响因素，为初始抗感染经验治疗提供参考依据。方法采用多中心调查的方法，收集2011年10月一2012年9月煤矿矿区4所医院呼吸内科102例确诊为CAP成人住院患者的临床资料，并采集急性期和间隔2～4周恢复期患者的静脉血进行非典型病原体抗体检测，应用SPSS13．0进行分析。结果102例CAP患者检出非典型病原体18株，阳性率为17．7％，其中肺炎支原体16株占15．7％，肺炎衣原体2株占2．0％；非典型病原体在18～49岁患者中的检出率高于≥50岁患者；非典型病原体在未合并其他疾病和肺炎严重指数（PORT）I级更常见，差异有统计学意义（P〈0．05）。结论煤矿矿区成人CAP患者的非典型病原体以肺炎支原体为主；对18～49岁年龄段、无基础疾病、PORTI级轻症CAP患者经验性抗感染治疗应涵盖非典型病原体。
OBJECTIVE To investigate the distribution of atypical pathogens and influencing factors of adult patients with community acquired pneumonia（CAP）in mining area, and provide reference for empirical therapy of CAP in initial infection period, METHODS Clinical data of 113 adult hospitalized patients with CAP in respiratory department from 4 hospitals in mining area, were collected retro spectively between Oct. 2011 to Sept. 2012 by multicenter survey method. Antibodies of the paired of 2～4 weeks serum samples to atypical pathogens were detected. SPSS13.0 software was used for statistical analysis. RESULTS A total of 18 strains （17.7%） atypical pathogens were isolated from 102 patients in CAP. The detection rates of Mycoplasma pneumoniae （MP） and Chlamydiae pneumonia （CP） were 15.7 % and 2.0% , respectively, and Legionella pneumoniae （LP） were not detected. The detection rates of atypical pathogens in 18 to 49 years old was higher than above 50 years old; atypical pathogens in the patient outcom research team（PORT） I level and without basic disease patients was more common （P〈0.05）. CONCLUSION The. Mp is the majority of atypical pathogens isolated from adult with CAP in mining area. With empirical antibiotic treatment, the patients of the age group from 18 to 49, no basic diseases, PORT I level should cover atypical pathogens.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2014年第15期3729-3730,3733,共3页
Chinese Journal of Nosocomiology
基金
中国煤炭工业协会科学技术研究指导性计划基金项目(MTKJ2011-459)
关键词
成人
社区获得性肺炎
非典型病原体
影响因素
Adult patient
Community-acquired pneumonia
Atypical pathogens
Influence factors
