摘要
目的 探讨RBP4与炎性因子水平对2型糖尿病下肢动脉病变的临床意义及诊断价值.方法 选择糖尿病患者118例,根据踝肱指数（ABI）分为单纯2型糖尿病组（A组,ABI 1.30 ～ 0.91）,中度闭塞组（B组,ABI 0.41～0.90）、重度闭塞组（C组,ABI ＜0.40）,分别有49例、38例、31例.分别检测各组RBP、ABI及IL-6、IL-8、TNF-仅.结果 B组RBP、ABI均较A组差异有统计学意义（P＜0.05）,C组RBP及ABI较A组及B组差异有统计学意义（P＜0.05）.B组IL-6、IL-8较A组差异有统计学意义（P＜0.05）,C组IL-6、IL-8、TNF-α较A、B组有升高（P＜0.05）.RBP与IL-6、IL-8、TNF-仅有相关性（P＜0.05）,ABI与IL-6、IL-8有相关性（P＜0.05）.结论 RBP4是判断2型糖尿病下肢动脉病变进展的重要指标,与炎性因子同时参与2型糖尿病下肢动脉病变的发展过程.
Objective To investigate the diagnostic value of RBP4 levels and inflammatory factors in type 2 diabetic with lower extremity arterial disease.Methods 118 cases were divided into simple type 2 diabetes group （A,ABI 1.30 ～ 0.91）,severe occlusion group （group B,ABI 0.41 ～ 0.90）,severe occlusion group （group C,ABI＜0.40） according to the ankle-brachial index （ABI）,there were 49 cases,38 cases,31 cases in the three groups,respectively.RBP,ABI,and IL-6,IL-8,TNF-α were detected in each group.Results There was significant difference in RBP and ABI between group A and group B （P＜0.05）,and between group C and group A and B （P＜0.05）.There was significant difference in IL-6 and IL-8 between group A and group B （P＜0.05）,and in the levels of IL-6,IL-8,TNF-α in group C were significantly higher than those in group A and B （P＜0.05）.RBP and IL-6,IL-8,TNF-α were significantly positively correlated （P＜0.05）,ABI and IL-6,IL-8 were significantly negatively correlated （P＜0.05）.Conclusions RBP4 can help to determine the type 2 diabetic patients with lower extremity arterial disease and work as an important indicator of progress,while inflammatory factors are involved in the development process of lower extremity arterial disease.
出处
《昆明医科大学学报》
CAS
2014年第8期99-102,共4页
Journal of Kunming Medical University
基金
陕西省科技攻关基金资助项目(2011K14-04-05)
