摘要
目的:分析我院常用中药注射剂常用辅料的作用与导致的不良反应,为临床合理用药提供参考。方法:查阅17种我院常用中药注射剂的说明书与近30年国内外文献,进行整理分析,总结我院中药注射剂常用辅料的安全性状况。结果:我院中药注射剂常用辅料主要作为等渗调节剂、填充剂、保护剂、增溶剂、抗氧化剂、pH调节剂等发挥作用,其中以聚山梨酯80、乙醇、丙二醇、维生素C等辅料为代表,分别存在外周神经毒性、中枢神经系统毒性、肝毒性、肾毒性、刺激性等不良反应。结论:中药注射剂中常用辅料与中药注射剂的不良反应密切相关,临床用药时应予以注意,正确制订给药方案。
OBJECTIVE： To analyze the functions and adverse reactions of commonly used excipients of traditional Chinese medicine injections in our hospital so as to provide reference for rational use of drugs. METHODS： The package inserts of 17 com- monly used traditional Chinese medicine injections in our hospital and the pertinent literature in recent 30 years both at home and abroad were retrieved for analysis, with the safety of the commonly used excipients of traditional Chinese medicine injections sum- marized. RESULTS： The commonly used excipients of traditional Chinese medicine injections in our hospital were mainly used as isoosmotic adjusting agents, loading agents, protecting agents, solubilizers, antioxidants and pH-adjusting agents, with polysorbate 80, ethanol, propylene glycol, vitamin C as representatives. The side effects of the excipients included toxicity in peripheral nerves, central nervous system, liver and kidney and irritation, etc. CONCLUSIONS： The excipients commonly used are closely related to the adverse reactions of traditional Chinese medicine injections, which should be given great attention in clinical use, meanwhile it is important to formulate correct dosing regimen.
出处
《中国医院用药评价与分析》
2014年第7期640-642,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
中药注射剂
辅料
不良反应
Traditional Chinese medicine injections
Excipients
Adverse reactions
