摘要
羟基喹啉羧酸酯类化合物是一类高效抗球虫化合物,在防治家禽球虫病方面发挥了重要的作用。而苯胺基亚甲基丙二酸二乙酯是羟基喹啉羧酸酯合成过程中的一类重要中间体,此类化合物对于新型羟基喹啉羧酸酯类抗球虫药物的开发具有重要意义。本文报道了一个新型2-(3-苯基-4-邻溴苯甲氧基)苯胺亚甲基丙二酸二乙酯的合成,其结构经1H NMR和HRMS证实。
4 -Hydroxyl -quinolinecarboxylates exerts potent anticoccdial activities , which was widely used in poultry industry.Substituted diethyl anilinomethylenemalonate was the key intermediate for the synthesis of 4-hydroxyl-quinolinecarboxylates , which was very important for the development of novel anticoccidial drugs.A new diethyl 2-（3-phenyl-4 -ortho -bromo -benzyloxyanilino ） methylenemalonate was designed and synthesized.The structure was confirmed by 1 H NMR and HRMS.
出处
《广州化工》
CAS
2014年第15期82-83,共2页
GuangZhou Chemical Industry
基金
四川省教育厅自然科学青年项目(12ZB128)
西华大学重点科研基金项目(Z1123328)
