摘要
目的 :探讨木犀草素(Luteolin)对乳腺癌细胞MDA-MB231增殖及IL-8信号通路的抑制作用。方法:采用不同浓度的Luteolin处理乳腺癌细胞MDA-MB231,观察MDA-MB231细胞的增殖、IL-8蛋白和m RNA的表达以及AKT、ERK的表达。结果:Luteolin可抑制MDA-MB231细胞的增殖和IL-8的分泌,并明显抑制IL-8对乳腺癌细胞的激活。结论:Luteolin是重要的乳腺癌抑制剂,在预防乳腺癌复发及转移中可能有重要的作用。
Objective：To study the inhibition of IL-8 signal pathway of luteolin in breast cancer cells MDA-MB231.Methods：Different concentrations of luteolin treatment of breast cancer cells MDA-MB231,observation of luteolin in breast cancer cells MDA-MB 231 cell expression of IL-8,and luteolin in breast cancer cells MDA-MB 231 IL-8 signal activation inhibition,explore the inhibition mechanism of luteolin in breast cancer cells MDA-MB 231.Results：The inhibitory effect of luteolin on breast cancer cell proliferation is significantly,luteolin can inhibit the expression of IL-8 in breast cancer cells,and significantly inhibited IL-8 activation of breast cancer cells.Conclu sion：Luteolin can inhibit breast cancer MDA-MB 231 cell proliferation,luteolin can inhibit the IL-8 signal activation of breast cancer cells show that luteolin is an important inhibitor of breast cancer,there may be important in the prevention of recurrence and metastasis of breast cancer.
出处
《中国现代普通外科进展》
CAS
2014年第6期435-438,共4页
Chinese Journal of Current Advances in General Surgery
