摘要
目的:探讨丹参酮(TⅡA)对癫痫大鼠认知功能障碍的治疗作用。方法:将24只成年雄性SD大鼠随机等分为健康对照组、模型组、TⅡA(每日10 mg/kg)治疗组。采用Morris水迷宫实验检测大鼠学习记忆功能,运用电生理技术在脑片水平检测海马CA1区长时程增强(LTP)。结果:(1)模型组大鼠在Morris水迷宫实验中寻找平台潜伏期明显长于健康对照组(P<0.05),TⅡA治疗组寻找平台潜伏期较模型组显著缩短(P<0.05)。空间探索试验中,模型组大鼠在目标象限的停留时间显著短于对照组(P<0.05),TⅡA治疗后大鼠在目标象限的停留时间较模型组明显延长(P<0.05)。(2)给予高频强直刺激(HFS)后各均可诱发LTP,且均持续1 h以上,与模型组比较缺氧组HFS刺激后LTP显著减弱(P<0.05),TⅡA治疗后LTP较模型组显著增强(P<0.05)。结论:TⅡA可显著改善癫痫大鼠认知功能障碍,该作用与TⅡA减轻癫痫大鼠海马LTP抑制有关。
Objective： To investigate the effects of Tanshinone Ⅱ A （T Ⅱ A） on cognitive deficits induced by Status Epilepticus. Methods： Twenty four male Sprague-Dawley rats（ 180 -220 ） were randomly divided into three groups with 8 rats in each group ： Control group, Model group and T Ⅱ A therapy group. Cognitive function was detected by the water maze task. Hippocampal CA1 LTP at brain slices was measured by electrophysiology method. Results： Status Epilepticus can cause severe cognitive deficits, and T Ⅱ A could improve the cognitive deficits induced by Status Epilepticus. LTP inhibition in hippocampus caused by Status Epilepticus were markedly attenuated by administration of T Ⅱ A. Conclusions： T Ⅱ A exhibits therapeutic potential for cognitive deficits induced by Status Epilepticus.
出处
《神经解剖学杂志》
CAS
CSCD
北大核心
2014年第4期452-456,共5页
Chinese Journal of Neuroanatomy
基金
新疆自治区自然科学基金(2014211A066)
