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黄病毒属病毒E蛋白结构和功能研究进展 被引量:6

Recent advances on the structure and function of E protein of Flaviviruses
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摘要 黄病毒属病毒是单股正链RNA病毒,病毒基因组编码至少三种结构蛋白(衣壳蛋白C、膜蛋白M和包膜蛋白E)和七种非结构蛋白。其中E蛋白是病毒的重要抗原成分,包含有中和抗原表位和型特异性抗原表位,决定了病毒的细胞嗜性和毒力,与病毒的吸附、穿入、致病等作用密切相关,并且具有血凝活性,能刺激机体产生中和抗体和血凝抑制抗体。研究E蛋白的结构与功能对于深入了解黄病毒致病机制和免疫应答特点,研发疫苗和特异性抗病毒药物均有重要的指导意义。为此,综述了近年来黄病毒E蛋白有关结构与功能的研究进展及其生物学意义。 The Flaviviruses are single-stranded positive-sense RNA encoding at least three structural proteins and seven non-structural proteins. As the major antigen of flaviviruses,the envelope( E) glycoprotein is involved in various biological events,such as virus attachment,fusion,penetration,hemogglutination,host range and cell tropism. The flavivirus E protein contains epitopes critical for eliciting neutralizing antibodies and hemogglutination inhibition antibodies against the viruses. Therefore the study on the structure and function of E protein will provide useful information for further understanding molecular mechanism of pathogenicity and feature of immune responses of flaviviruses as well as developing vaccines and anti-viral drugs. This short review will focus on the recent advancement of the structure and function of flavivirus E protein and its biological significance.
出处 《微生物学免疫学进展》 2014年第3期49-53,共5页 Progress In Microbiology and Immunology
基金 国家自然科学基金资助(81171557)
关键词 黄病毒 E蛋白 Flavivirus Envelope protein
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  • 1朱武洋,秦鄂德.黄病毒衣壳蛋白研究进展[J].国际病毒学杂志,2006,13(2):47-50. 被引量:6
  • 2邓永强,秦鄂德.虫媒黄病毒包膜E蛋白的研究进展[J].军事医学科学院院刊,2006,30(6):575-579. 被引量:20
  • 3Alcon S, Talarmin A, Debruyne M, Falconar A, Deubel V, Flamand M. 2002. Enzyme-linked immunosorbent assay specific to dengue virus type 1 nonstructural protein NSI reveals circulation of the antigen in the blood during the a- cute phase of disease in patients experiencing primary or secondary infections [ J ]. Journal of Clinical Microbiology, 40(2 ) : 376-381.
  • 4Alcon-Lepoder S, Sivard P, Drouet M T, Talarmin A, Rice C, Flamand M. 2006. Secretion of flaviviral non-structural protein NSI: from diagnosis to pathogenesis[J ]. Novartis Foundation Symposium, 277: 233-247.
  • 5Chu J, Rajamanonmani R, Li J, Bhuvanakantham R, Lescar J, Ng M L. 2005. Inhibition of West Nile virus entry by using a recombinant domain III from the envelope glycopro- tein[J]. The Journal of General Virology, 86(2): 405-412.
  • 6Guirakhoo F, Heinz F X, Kunz C. 1989. Epitope model of tick- borne encephalitis virus envelope glycoprotein E: Analysis of structural properties,role of carbohydrate side chain,and conformational changes occurring at acidic pH[J ]. Virology, 169( 1 ) :90-99.
  • 7Huang X, Han K, Zhao D, Liu Y, Zhang J, Niu H, Zhang K, Zhu J, Wu D, Gao L, Li Y. 2013. Identification and molecular characterization of a novel flavivirus isolated from geese in china[J ]. Research in Veterinary Science, 94(3): 774-780.
  • 8Kolaskar A S, Kulkarni-Kale U. 1999. Prediction of three-Di- mensjonal structure and mapping of conformational epitopes of envelope glycoprotein of Japanese encephalitis virus[J]. Virology, 261 ( 1 ) : 31-42.
  • 9Ledizet M, Kar K, Foellmer H G, Wang T, Bushmich S L, Anderson J F, Fikrig E, Koski R A. 2005. A recombinant envelope protein vaccine against West Nile virus [J]. Vac- cine, 23(30): 3915-3924.
  • 10Mutoh E, Ishikawa T, Takamizawa A, Kurata T, Sata T, Ko- jima A. 2004. Japanese encephalitis subunit vaccine com- posed of virus-like envelop antigen particles purified from serum-free medium of a high-producer J12#26 cell clone [J]. Vaccine, 22(20):2599-2608.

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