摘要
目的探讨降钙素原(PCT)对重症患者合并脓毒症的早期诊断的临床价值和意义。方法选择2012年10月—2013年10月急诊入住ICU符合全身炎症反应综合征(SIRS)的重症患者69例为研究对象,根据脓毒症的诊断标准分为脓毒症组31例和非脓毒症组38例,所有患者分别在第1、3、5 d均检测PCT、C反应蛋白(CRP)和外周血白细胞(WBC)计数。结果脓毒症组的PCT与APACHEⅡ评分明显高于非脓毒症组,2组比较差异有统计学意义(P<0.01);CRP和WBC计数在2组均有升高,但差异无统计学意义(P>0.05)。PCT诊断脓毒症的敏感性为96.70%,特异性为60.5%,均高于CRP和WBC。结论PCT可以作为判断重症患者合并脓毒症的早期诊断指标,其敏感性和特异性明显优于CRP和WBC计数。
Objective To evaluate the diagnostic value and the significance of procalcitonin （PCT） on critical patients combined with severe sepsis.Methods From October 2012 to October 2013,69 critical patients hospitalized at intensive care unit （ICU） and conformed with systemic inflammatory response syndrome （SIRS） were divided into sepsis group and non-sepsis group,according to diagnostic criteria of sepsis.Blood specimen were collected from each patient for the measurement of serum levels of PCT,C-reactive protein （CRP） and white blood cell count （WBC） on 1 day,3 day and 5 day after hospitalization.Results Serum level of PCT and APACHE Ⅱ in sepsis group increased more significantly than non-sepsis group （P ＜ 0.01）,while serum levels of CRP and WBC increased in both groups,but there was no statistically significant difference （P ＞0.05）.Sensitivity and specificity of PCT on diagnosing severe sepsis were 96.7 ％ and 60.5 ％ respectively,both higher than those of CRP and WBC.Conclusion PCT could be the early indicator that diagnose severe sepsis in critical patients,the sensitivity and specificity of PCT is higher than those of CRP and WBC.
出处
《实用临床医药杂志》
CAS
2014年第11期40-42,共3页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11321673)
关键词
降钙素原
脓毒症
C反应蛋白
白细胞计数
诊断
procalcitonin
severe sepsis
C-reactive protein
white blood cell count
diagnosis
