摘要
目的探讨双环醇联合阿德福韦酯治疗慢性乙型肝炎(CHB)的疗效。方法 120例CHB患者随机分为观察组和对照组,每组60例。对照组给予口服阿德福韦酯胶囊,观察组给予口服阿德福韦酯胶囊联合口服双环醇片。比较2组患者治疗前和治疗后第48周时的HBV-DNA阳性率、HBeAg阳性率,比较2组治疗前,治疗第4、24、48周的血清谷丙转氨酶(ALT)水平。结果 2组患者治疗后各时点的ALT水平均显著低于治疗前(P<0.05),且观察组ALT水平均显著低于对照组(P<0.05);治疗后第48周,观察组患者的HBV-DNA阳性率和HBeAg阳性率显著低于对照组(P<0.05)。结论双环醇联合阿德福韦酯能显著抑制HBV增殖,保护肝细胞,降低CHB对患者肝功能的损害。
Objective To explore the effect of bicyclol combined with adefovir dipivoxil on the treatment of the patients with chronic hepatitis B（ CHB）. Methods 120 CHB patients were randomly divided into the observation group and the control group,60 cases in each group. The control group was treated with adefovir dipivoxil capsules,while the observation group was treated with adefovir dipivoxil capsules combined with bicyclol tablets. The positive rates of HBeAg and HBV- DNA before the treatment and at 48 th week after the treatment were compared between two groups,and the serum alanine aminotransferase（ ALT） level before the treatment and at 4th,24 th,48th week after the treatment was compared as well. Results ALT level in both groups at different time points were significantly lower than those before the treatment（ P〈 0. 05）,and the ALT levels at the different time points in the observation group were significantly lower than those of the control group（ P〈 0.05）. At 48 th week after the treatment,the positive rates of HBV- DNA and HBeAg in the observation group were significantly lower than those in the control group（ P〈 0. 05）. Conclusion Application of bicyclol combined with adefovir dipivoxil can significantly inhibit the proliferation of HBV,protect the liver cells and reduce the damages of CHB to the liver function.
出处
《实用临床医药杂志》
CAS
2014年第15期110-112,共3页
Journal of Clinical Medicine in Practice
关键词
慢性肝炎乙型
阿德福韦酯
双环醇
疗效
chronic hepatitis B
adefovir dipivoxil
bicyclol
efficacy
