摘要
目的:观察独活寄生汤加减联合膝关节穿刺腔内注射玻璃酸钠对老年性膝骨关节炎的近、远期临床疗效。方法:将120例老年性膝骨关节炎患者随机分为治疗组和对照组,每组60例。对照组给予膝关节穿刺腔内注射玻璃酸钠治疗,治疗组在对照组治疗基础上加服独活寄生汤加减治疗,两组均以5周为1个疗程。1个疗程后,观察两组患者的近期疗效,并评价两组患者的膝关节疼痛、压痛、肿胀、晨僵、行走能力。1年后随访两组患者的远期疗效。结果:治疗后,治疗组治愈18例,显效23例,有效16例,无效3例,有效率95.00%;对照组治愈17例,显效14例,有效19例,无效10例,有效率83.33%。两组近期疗效比较,差异无统计学意义(χ2=6.24,P>0.05)。两组膝关节疼痛、压痛、肿胀、晨僵、行走能力分值比均有改善,且治疗组优于对照组(P<0.05)。1年后随访远期疗效,治疗组优于对照组(P<0.05)。结论:膝关节穿刺腔内注射玻璃酸钠对老年性膝骨关节炎近期有显著的效果,但远期效果不能确定;联合口服独活寄生汤加减能明显提高其远期疗效,临床上可根据具体情况加以运用。
Objective：To observe the clinical curative effects of modified Duhuo Jisheng Decoction combined with knee joint cavity injection of medical sodium hyaluronate in the treatment of senile knee osteoarthritis in the near and long terms.Methods： 120 cases of senile knee osteoarthritis were randomly and equally divided into a treatment group and a control group.The control group were given the knee joint cavity injection of medical sodium hyaluronate,while the treatment group were given modified Duhuo Jisheng Decoction based on the treatment of the control group.Both groups were treated for 5 weeks as a course.After 1 course of treatment,the short-term curative effects in the two groups was observed and the knee joint pain,tenderness,sw elling,morning stiffness,walking ability of the two groups were evaluated. 1 year later, follow-up for the longterm effect of the two groups.Results：After treatment,in the treatment group,18 cases were recovery,23 cases were markedly effective,16 cases were effective and 3 cases were invalid,the effective rate being 95.00%.1n the control group,17 cases were recovery,14 cases were markedly effective,19 cases were effective and 10 cases were invalid,the effective rate being 83.33%,there being no significant difference between the two groups in the short term （ X^2 = 6.24,P 〉 0.05 ） .The knee joint pain,tenderness,swelling,morning stiffness and walking ability of the two groups were all improved,with the treatment group better than the control group （ P 〈 0.05 ） .According to the follow-up for the long-term effect 1 year later, the treatment group was better than the control group（ P 〈 0.05 ）.Conclusion：The knee joint cavity injection of sodium hyaluronate had a significant effect on senile knee osteoarthritis in the near term,but that of the long term was uncertain;its combination with modified Duhuo Jisheng Decoction could obviously improve the long-term efficacy, which could be used clinically according to specific situations
出处
《风湿病与关节炎》
2014年第8期12-14,24,共4页
Rheumatism and Arthritis
关键词
骨关节炎
膝
独活寄生汤
膝关节穿刺
玻璃酸钠
osteoarthritis,knee
Duhuo Jisheng Decoction
knee joint puncture
sodium hyaluronate
