摘要
汉黄芩素是一种天然黄酮类化合物。最近研究发现,汉黄芩素具有广泛的抗肿瘤作用,其作用显示出多途径、多环节、多靶点的特点;如可通过ROS途径和Ca2+介导的信号通路促进肿瘤细胞的凋亡、增强TNF-α和TRAIL对肿瘤细胞的毒性、阻滞肿瘤细胞的细胞周期、抑制肿瘤血管生成、协同化疗药物抗癌活性等。另外,汉黄芩素可通过增加免疫细胞的浸润、调节免疫细胞的表型、以及促进相关细胞因子的分泌来增强免疫功能。该文就汉黄芩素抗肿瘤和免疫增强活性的研究进展进行了综述。
Wogonin is a kind of natural flavonoid compound. According to findings in the latest studies,wogonin shows a wide range of antitumor effects,with the characteristics of multi-pathway,multi-link and multi-target,such as promoting tumor cell apoptosis through ROS or Ca2 ＋-mediated signal paths,enhancing tumor cytotoxicity by TNF-α and TRAIL,blocking tumor cell cycle,inhibiting tumor angiogenesis and resisting cancer synergistically with chemotherapeutic drugs. Moreover,Wogonin could enhance body immune function by enhancing immune cell infiltration,regulating the immune cell phenotype and promoting relevant cytokine secretion. In this paper,the authors summarized the advance in studies on wogonin’s antitumor and immunomodulatory effects.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2014年第16期3004-3009,共6页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(30873343)
扬州市社会发展科技攻关项目(YZ2010088)
扬州市医学重点人才项目(扬卫医[2013]28号)
