摘要
目的 建立福建省泉州地区甲状腺抗体阴性正常孕妇孕期前、中、后3个月间期甲状腺激素水平正常参考值范围。方法 选取福建省泉州地区甲状腺抗体阴性孕4-39周妇女490例,应用电化学发光法检测其妊娠前、中、后3个月间期血清FT4、FT3、TSH、TPOAb水平,另选非孕期妇女51例作为对照,建立甲状腺抗体阴性妇女甲状腺激素水平正常参考值范围。结果 不同孕期孕妇TPOAb中位数均在厂家提供参考区间内。其血清FT3、FT4水平在孕期前、中、后3个月呈逐渐降低（P〈0.01）;血清TSH水平自孕前期3个月至孕末期3个月呈逐渐升高（P〈0.01）;非孕期妇女甲状腺激素水平明显高于孕前期3个月水平（P〈0.01）,而低于孕中期和孕后期3个月水平（P〈0.01）。在妊娠前、中、后3个月间期,泉州地区甲状腺抗体阴性正常孕妇FT3正常参考值范围分别为3.75-7.23、3.31-4.93和3.16-4.48 pmol/L;FT4分别为12.85-25.3、12.03-20.14和11.02-19.43 pmol/L;TSH分别为0.01-3.79、1.09-4.19和1.08-5.95 mU/L。结论 通过本次测定,我们建立了泉州地区甲状腺抗体阴性甲状腺激素水平的孕期前、中、后3个月间期甲状腺激素正常参考值。
Objective To set reference intervals of the levels of thyroid hormones among normal pregnant women without presence of thyroid antibodies during three trimesters of pregnancy in Quanzhou city, Fujian province. Methods A total of 490 pregnant women during 4-39 week pregnancy without presence of thyroid antibodies were enrolled in Quanzhou city, Fuiian province. Levels of thyroid stimulating hormone （TSH）, free triiodothyronine （FT3）, free thyroxine （FT4） and thyroid peroxidase antibodies （TPO-Ab） were detected through the electrochemistry immunoassay （ECL） method. In addition, a total of 51 healthy women without pregnancy were enrolled to set the reference intervals of levels of thyroid hormones among normal pregnant women without presence of thyroid antibodies. Results The median levels of TPO-Ab were in the reference intervals provided by the pharmaceutical factory. Levels of FT3 and FT4 gradually decreased from the first to the third trimester （P〈0.01）, levels of serum TSH gradually increasd from the first to the third trimester （P〈0.01）. Compared with those of pregnant women, levels of thyroid hormone in normal non-pregnant women were higher in the first trimester, lower in the second and the third trimesters （P〈0.01）. During three trimesters, the reference intervals of FT3 in the three trimesters were （first： 3,75 to 7.23; second 3.31 to 4.9; and third： 3.16 to 4.48 pmol/L）; the reference intervals of FT4 were （first： 12.85 to 25.3; second： 12.03 to 20.14; and third： 11.02 to 19.43 pmol/L）; and the reference intervals of TSH were （first： 0.01 to 3.79; second： 1.09 to 4.19; and third： 1.08 to 5.95 mIU/L）, respectively. Conclusion Through this detection, we set the levels of thyroid hormones among normal pregnant women without presence of thyroid antibodies during three trimesters of pregnancy in Quanzhou city.
出处
《中国循证医学杂志》
CSCD
2014年第8期919-922,共4页
Chinese Journal of Evidence-based Medicine
关键词
妊娠
甲状腺激素
正常参考值
泉州
Pregnancy
Thyroid hormone
Normal reference interval
Quanzhou
