摘要
目的探讨金丹盆乐汤灌肠联合熏蒸疗法对慢性盆腔炎患者血清肿瘤坏死因子-α(TNF-α)和白细胞介素-2(IL-2)水平的影响。方法选取120例慢性盆腔炎患者,采用金丹盆乐汤灌肠联合熏蒸治疗的62例患者为观察组,采用康妇消炎栓肛塞治疗的58例患者为对照组,比较两组治疗效果和血清TNF-α、IL-2水平的变化。结果观察组一个疗程、两个疗程后的临床总有效率均优于对照组(x^2值分别为5.16、4.85,均P<0.05),观察组和治疗组患者治疗两个疗程后的效果均优于一个疗程(x^2值分别为15.50、10.35,均P<0.05)。观察组和治疗组患者治疗后血清TNF-α水平均下降(t值分别为2.45、1.74,均P<0.05),而血清IL-2水平均上升(t值分别为4.04、1.75,均P<0.05)。进一步比较两组患者治疗后血清TNF-α、IL-2水平,发现观察组血清TNF-α水平较对照组下降(t=3.84,P<0.05),而血清IL-2水平较对照组上升(t=4.12,P<0.05)。观察组患者治疗后腰骶部胀痛、下腹部胀痛、盆腔压痛改善情况优于对照组(x^2值分别6.24、5.34、5.04,均P<0.05),两组白带量增多改善情况比较差异无统计学意义(x^2=0.99,P>0.05)。结论金丹盆乐汤灌肠联合熏蒸疗法治疗慢性盆腔炎疗效显著,可明显调节血清TNF-α和IL-2水平,改善患者的临床症状。
Objective To investigate the effect of Jindanpenle soup clyster combined with fumigation and steaming therapy on serum tumor necrosis factor -α （TNF-α） and interleukin 2 （IL-2） levels of patients with chronic pelvic inflammatory disease （CPID）. Methods Among 120 patients with CPID, 62 cases were in observation group treated with Jindanpenle soup clyster combined with fumigation and steaming therapy, and the other 58 cases were in control group with Kangfu anti-inflammatory. The therapeutic effect and the changes of serum TNF- α and IL-2 levels were compared between two groups. Results The total clinical effective rates in the observation group after one and two courses of treatment were superior to those in the control group （X2 was 5.16 and 4.85, respectively, both P 〈 0.05）. The total clinical effective rates after two courses of treatment were significantly superior to those after one course of treatment in two groups （X2 was 15.50 and 10.35, respectively, both P 〈 0.05 ）. After treatment the serum TNF-α level decreased significantly （ t value was 2.45 and 1.74, respectively, both P 〈 0.05） and serum IL-2 level increased significantly （ t value was 4.04 and 1.75, respectively, both P 〈 0.05） in two groups. Comparison between two groups showed that the serum TNF-α level decreased more significantly （ t = 3.84, P 〈 0.05 ） and serum IL-2 level increased more significantly （t = 4.12 ,P 〈 0. 05 ） in the observation group than in the control group. The improvement of lumbosaera] area pain, lower abdominal pain and pelvic tenderness in the observation group was significantly superior to the control group （X2 value was 6.24, 5.34 and 5.04, respectively, all P 〈 0.05 ） , but there was no significant difference in the improvement of increased quantity of leucorrhea in two groups （X2 = 0.99, P 〉 0.05 ）. Conclusion Jindanpenle soup clyster combined with fumigation and steaming therapy has remarkable effect on patients with CPID, and it can modify the serum TNF-α and IL-2 levels obviously and then improve the clinical symptoms of patients.
出处
《中国妇幼健康研究》
2014年第4期656-658,共3页
Chinese Journal of Woman and Child Health Research
关键词
金丹盆乐汤
熏蒸疗法
慢性盆腔炎
肿瘤坏死因子-α
白细胞介素-2
Jindanpenle soup
fumigation and steaming therapy
chronic pelvic inflammatory disease （CPID）
tumor necrosis faetor-α （TNF-α）
interleukin-2 （IL-2）
