摘要
回顾分析249例子宫内膜癌及99例子宫肌瘤患者术前血清人附睾蛋白4（HE4）、糖链蛋白 （CA） 125和CA19-9的水平子宫内膜癌术前血清HE4、CA125及CA19-9水平显著高于对照组.血清HE4、CA125和CA19-9单独检测的受试者工工作特征曲线下面积（AUC）分别为0.736、0.615、0.661,三项联合的AUC为0.774,显著高于任一指标.在特异度为90％时,血清HE4、CA125和CA190的灵敏度分别为55.0％、26.9％、30.1％,而联合检测的灵敏度为56.2％ 血清HE4是子宫内膜癌的理想标记物,联合CA125和CA19-9有助于提高术前诊断水平.
Preoperative serum specimens were collected from 249 endometrial cancers and 99 uterine leiomyomas and their concentrations of human epididymis protein 4 （HE4）,CA 125 and CA 19-9 were detected.The indices of diagnostic evaluation were calculated.Preoperative serum concentrations of HE4,CA125 and CA19-9 in endometrial carcinoma group were significantly higher than those of control group.The areas under curve of HE4,CA125 and CA19-9 were 0.736,0.615 and 0.661 respectively and that of combiued markers was 0.774.At a 90% specificity,the sensitivities for HE4,CA125,CA19-9 were 55.0%,26.9% and 30.1% while that of combined markers was 56.2%.HE4 is an ideal tumor marker for endometrial cancer and combined detection improves diagnostic rate.
出处
《中华全科医师杂志》
2014年第8期695-697,共3页
Chinese Journal of General Practitioners
关键词
子宫内膜癌
肿瘤指标
Endometrial cancer
Tumor marker
