摘要
猪链球菌病是由猪链球菌引起的一种人畜共患病,不仅给养猪业的健康发展造成极大的危害,还严重威胁着人类的公共卫生安全,已经引起人们的高度重视。目前,发现和鉴定新的毒力因子成为国内外猪链球菌研究的重点。论文主要对猪链球菌相关毒力因子荚膜多糖、溶菌酶释放蛋白、胞外因子、溶血素及近几年新发现的相关毒力因子荚膜唾液酸、Cbp40、VirA、pgdA、Trag、溶血素相关基因、CiaRH、CcpA、TroA进行综述。通过总结毒力因子对猪链球菌致病机理的影响,以期为猪链球菌病的治疗及疫苗的研制提供理论基础。
Porcine streptococcosis,a zoonotic disease caused by Streptococcus suis,not only does great harm to the development of pig industry,but also is an important threat to public health security.Now this disease has caught public attention.In recent years,the detectioin and identification of new virulence factors has become the focus of research at home and abroad.This paper focused on the relevant virulence factors of Streptococcus suis,such as capsular polysaccharide（CPS）,muramidase-released protein（MRP）,extracellular protein factor（EF）,suilysin（SLY）and new virulence-associated gene sequences and proteins found lately,containing capsular sialic acid,Cbp40,VirA,pgd A,Trag,hemolsis-related gene,CiaRH,CcpA,TroA.This paper summarized the effects of these virulence factors on the mechanisms in pathogenesis of Streptococcus suis,providing a theoretical basis for the treatments and development of vaccine.
出处
《动物医学进展》
CSCD
北大核心
2014年第8期95-99,共5页
Progress In Veterinary Medicine
关键词
猪链球菌
毒力因子
致病机制
Streptococcus suis
virulence factor
pathogenic mechanism
