摘要
目的观察注射用头孢唑林钠和五水头孢唑林钠在6种溶媒中的稳定性,为临床合理配置使用头孢唑林钠提供依据。方法将注射用头孢唑林钠分别加入0.9%氯化钠注射液、5%葡萄糖注射液、乳酸钠林格注射液、木糖醇注射液、转化糖电解质注射液、果糖注射液,在25、40℃下观察溶液6 h内的外观,测定pH值,用高效液相色谱法测定头孢唑林钠在溶媒中的质量分数。结果 25℃和40℃下6 h内头孢唑林钠在6种溶媒中的质量分数均大于95%,配制液pH值、外观无明显变化;在40℃下6 h后头孢唑林钠质量分数小于90%,并随时间延长呈下降趋势。配制液pH值也有所下降。结论注射用头孢唑林钠在0.9%氯化钠注射液、5%葡萄糖注射液、乳酸钠林格注射液、木糖醇注射液、果糖注射液、转化糖电解质注射液中40、25℃下6 h内是稳定的。注射用头孢唑林钠加入上述溶媒后应在6 h内输注完毕,高温环境下应现配现用。
Objective To study the stability of Cefazolin Sodium for injection and Pentahydrate Cefazolin Sodium for injection in six kinds of solvents, and to provide evidence for clinical rational use of cefazolin sodium.Methods Cefazolin Sodium for injection was added in 0.9% Sodium Chloride Injection, 5% Glucose Injection, Sodium Lactate Ringer’s Injection, Xylitol Injection, Multiple Electrolytic and Invert Sugar Injection, and Fructose Injection. The appearance, pH values, and contents of cefazolin sodium were observed within 6 h at 25 and 40℃. The contents of cefazolin sodium in Cefazolin Sodium for injection samples in the media were obtained by HPLC methods.Results The contents of cefazolin sodium in six kinds of solvents at 25 and 40℃ during 6 h were above 95%. There were no significant changes in appearance and pH value during 6 h. At 40℃ content of cefazolin sodium was below 90% after 6 h and decreased with the change of time. The pH value of configuration solution also increased.Conclusion Cefazolin Sodium for Injection in 0.9% Sodium Chloride Injection, 5% Glucose Injection, Sodium Lactate Ringer’s Injection, Xylitol Injection, Fructose Injection, and Multiple Electrolytic and Invert Sugar Injection at 40 and 25℃ during 6 h is stable. The solvents with Cefazolin Sodium for injection should be infused within 6 h, and they should be prepared when using as the environment is in the condition of high temperature.
出处
《现代药物与临床》
CAS
2014年第7期813-817,共5页
Drugs & Clinic
基金
中国中日科技交流协会科研课题(2013-2015年)
关键词
注射用头孢唑林钠
注射用五水头孢唑林钠
头孢唑林钠
氯化钠注射液
葡萄糖注射液
稳定性
Cefazolin Sodium for injection
Pentahydrate Cefazolin Sodium for injection
cefazolin sodium
Sodium Chloride Injection
Glucose Injection
stability
