摘要
结肠癌变的发生率在全球范围内呈明显上升趋势.除了与遗传、环境等因素有关,饮食结构也起到重要作用.流行病理学和现代分子生物学相关研究表明人体肠道内短链脂肪酸,特别是丁酸的浓度对维持肠道内环境起到重要作用.丁酸抑制肿瘤的首要机制是作为组蛋白去乙酰化酶(histone deacetylase)的抑制剂,但深入的研究显示丁酸还能有效地参与细胞的代谢并起到诱导结肠癌细胞凋亡及抗增殖作用.为此,本文将针对丁酸对结肠细胞的作用机制进行综述.
There is an increasing trend for the incidence of bowel diseases around the world. Besides the influence from family background and environment, dietary structure plays important roles in the rising rates of bowel diseases. Results from epidemiological studies and molecular biological studies showed that the concentration of shortchain fatty acids, in particular butyrate, is a key factor for maintaining a healthy colon environment. Although the primary mechanism for butyrate to depress the growth of cancer cells is acting as an inhibitor of histone deacetylases（HDACs）, some studies demonstrated that butyrate is also involved in cell metabolism and induction of the death of cancer cells. This article reviews the mechanisms of action of butyrate on colon cells.
出处
《世界华人消化杂志》
CAS
北大核心
2014年第18期2539-2546,共8页
World Chinese Journal of Digestology
关键词
膳食纤维
丁酸
结肠癌
调控
Dietary fiber
Butyrate
Colon cancer
Regulation
