摘要
目的:探讨肝癌切除联合断流术治疗原发性肝癌合并门静脉高压症的临床疗效.方法:收集2011-01/2013-12我院收治的原发性肝癌合并门静脉高压症患者50例,其中,采取单纯肝癌切除术治疗20例(对照组),采取肝癌切除联合断流术治疗30例(观察组).回顾性分析两组的临床治疗效果.结果:治疗前观察组和对照组的白细胞计数(white blood cell count,WBC)、血小板(blood platelet,PLT)比较无明显的差异(P>0.05),统计学无意义;治疗后观察组和对照组的WBC、PLT较治疗前有明显的改善,观察组改善程度优于对照组,差异有统计学意义(P<0.05).治疗前观察组和对照组谷丙转氨酶(alanine aminotransferase,ALT)、谷草转氨酶(aspartate transaminase,AST)和总胆红素(total bilirubin,TB)以及白蛋白(albumin,ALB)比较无明显的差异(P>0.05),统计学无意义;治疗后观察组和对照组ALT、AST和TB以及ALB均较治疗前有明显的改善,但是术后组间的数据比较差异无统计学意义(P>0.05).观察组手术时间和治疗费用均明显地高于对照组,差异有统计学意义(P<0.05);观察组和对照组住院时间比较无明显差异(P>0.05).观察组并发症发生率为16.7%;对照组并发症发生率为15.0%.两组术后并发症发生率比较无明显的差异(P>0.05).结论:临床中原发性肝癌合并门静脉高压症患者采取肝癌切除联合断流术治疗效果显著,有效地改善患者血常规指标,值得临床中应用与推广.
AIM： To investigate the clinical efficacy of hepa-tectomy combined with devascularization in the treatment of primary liver cancer with portal hypertension. METHODS： Fifty hepatocellular carcinoma pa-tients with portal hypertension treated at our hospital between January 2011 and December 2013-12 were randomly divided into either a study group（n = 30） or a control group（n = 20）. The control group underwent hepatectomy only, and the study group underwent hepatectomy combined with devascularization. Clinical re-sults were compared between the two groups.RESULTS： There were no significant differences between the treatment group and control group with regard to white blood cell（WBC） count and platelet（PLT） before treatment（P〉0.05）. TheWBC and PLT were improved after treatment in both groups, and the improvement was bet-ter in the treatment group（P〈0.05）. There were no significant differences between the treatment group and control group before treatment with regard to alanine aminotransferase（ALT）, aspar-tate transaminase（AST）, total bilirubin（TB） and albumin（P〉0.05）; all these parameters were improved after treatment in both groups, and there were no statistical significances in these parameters between the two groups after treat-ment（P〉0.05）. The operative time and treat-ment costs were significantly higher in the treat-ment group than in the control group（P〉0.05）, although there was no significant difference in hospitalization time（P〈0.05）. The incidence of complications showed no significant difference between the two groups（16.7% vs 15.0%, P〉0.05）.CONCLUSION： Hepatectomy combined with devascularization is effective in the management of hepatocellular carcinoma patients with portal hypertension.
出处
《世界华人消化杂志》
CAS
北大核心
2014年第19期2780-2783,共4页
World Chinese Journal of Digestology
关键词
原发性肝癌
门静脉高压症
肝癌切除术
断流术
临床疗效
Primary liver cancer
Portal hypertension
Liver cancer resection
Revascularization
Clinical efficacy
