摘要
目的:本研究旨在探讨使用丹红注射液对急性冠状动脉综合征患者Ⅱb/Ⅲa血小板糖蛋白受体等的影响,了解丹红注射液在抗凝、活血化瘀的临床作用。方法:将我院心血管内科收治的72例急性冠状动脉综合征的患者随机的分成观察组和对照组各36例,对照组采用常规西医疗法(抗凝、抗血小板聚集、降脂、扩冠、降低心肌耗氧、改善心脏重塑等),观察组在对照组的基础上加用丹红注射液静脉滴注,每日1次,比较两组患者治疗前和治疗两周后血小板聚集率(PAR)、Ⅱb/Ⅲa血小板糖蛋白受体复合物(CD41)、P选择素(CD62p)、溶酶体膜糖蛋白(CD63)、基质金属蛋白酶(MMP-s)及心绞痛症状改善效果的差异。结果:PAR、CD41、CD62p、CD63、MMP-s进行检测分析,结果:治疗前后两组各指标行组内对比差异均有统计学意义(P<0.05),两组各指标治疗后明显好转;治疗2周以后两组各指标组间对比,PAR、CD63在两组间差异不具有显著意义(P>0.05),CD41、CD62p、MMP-s治疗组治疗后的效果明显优于对照组,差异具有统计学意义(P<0.05);观察组在疗效分布上观察组的总有效率显著高于对照组(P<0.05)。结论:使用丹红注射液对急性冠状动脉综合征患者进行治疗能够明显提高对ACS患者的临床疗效,各种Ⅱb/Ⅲa血小板糖蛋白受体等相关指标好转明显。
Objective ： This study examined the effects of using Danhong Injection to treat patients with acute coronary syndrome on Ⅱ b/Ⅲ a platelet glycoproteinreceptor, to investigate the clinical effect of Danlong Injection on anti-coagulation, promoting blood circulation and removing blood stasis. Methods ： The cardiovascular department of internal medicine in our hospitaltreated 72 cases of acute coronary artery syndrome were randomly divided into observation group and controlled group with 36 cases in each group, the controlled group used conventional western medicine therapy （ anticoagulant, lipid-lowering） , on the basisi of the controlled group , the observation group treated with Danlong Injection for intravenous drip, once daily, compared two groups of patients before treatment and 2 weeks after the platelet aggregation rate （P AR） , platelet glyeoprotein Ⅱ b/Ⅲ a receptor complex （CD41）, P selectin （CD62p）, lysosomal membrane glycoprotein （CD63）, matrix metalloproteinase （MMPs） and the difference of anginaimprovement. Results： PAR, CI41, CD62p, CD63, MMP-s were detected and analyzed. Results ： The two groups before and after treatment of each index for within group differences were valid statistical significance （ P 〈0.05 ）, the two groups after treatment significantly improved ; treatment for 2 weeks after the two groups were compared, PAR, CD63 in no difference among the two groups had the remarkable significance （ P 〉0.05 ）, significantly better than the controlled group CIM1, CD62p, MMP-s treatment group, the difference was statistically significant （P 〈0. 05） ; the observation group showed the proportion, in effect on the effective, efficient distribution ratio were significantly better than the controlled group, and the difference was statistically significant （ P 〈0. 05 ）. Conclusion ： The use of Danhong Injection therapy can significantly improve the clinicalcurative effects on ACS in patients with acute coronary syndrome, correlation index Ⅱb/Ⅲ a platelet glycoprotein receptor improvedobviously.
出处
《四川中医》
2014年第7期165-167,共3页
Journal of Sichuan of Traditional Chinese Medicine
