摘要
目的：探讨乙型肝炎血清免疫标志物、乙型肝炎病毒核酸水平变化与HBV的关系及临床意义。方法选取本院2013年2月∽2014年2月收治的108例乙型肝炎患者为研究对象,按HBV DNA含量高低分为A（〈103拷贝/ml）、B（103∽105拷贝/ml）、C（106∽108拷贝/ml）3组,分别检测3组的乙型肝炎血清免疫标志物（HBV M）与乙型肝炎病毒核酸（HBV DNA）含量。结果 A组的HBeAg为（3.971±14.47）S/CO,B组为（446.7±785.8）S/CO,两组比较,差异有统计学意义（P〈0.05）；A组的抗-HBe、HBeAg、HBsAg与C组比较,差异均有统计学意义（P〈0.05）；B组的HBeAg与C组比较,差异有统计学意义（P〈0.05）；3组的抗-HBs、抗-HBc比较,差异均无统计学意义（P〉0.05）。HBV M阳性标本中抗-HBs、抗-HBc与HBsAg含量与HBV DNA无相关性,抗-HBe与HBV DNA呈负相关,HBeAg与HBV DNA呈正相关。结论定量检测HBV DNA可真实反映HBV的复制情况,对于传染性评价、乙型肝炎诊治及疗效观察均具有指导意义；定量检测HBV M虽在HBV复制程度的判断及传染性评价方面无明显价值,但可为乙型肝炎数据管理奠定基础。
Objective To explore the relationship between serum immune marker of hepatitis B,level change of hepati-tis B virus nucleic acid and clinical significance. Methods 108 patients with hepatitis B admitted and treated in our hospital from February 2013 to February 2014 were selected as research objects.The patients were assigned to the three groups according to HBV DNA level：the group A （〈103 copy/ml）,the group B （103-105 copy /ml） and the group C （106-108 copy/ml）.The serum immune marker of hepatitis B （HBV M） and hepatitis B virus nucleic acid （HBV DNA） content were tested for each group. Results HBeAg in the group A and the group B was （3.971±14.47） S/CO and （446.7±785.8） S/CO respectively,and there was a statistical difference in the two groups （P〈0.05）.The group A and the group C had a statistical difference in anti-HBe,HBeAg and HBsAg level （P〈0.05）.The group B and the group C had statistical differ-ence in HBeAg level （P〈0.05）.There was no statistical difference between the three groups in anti-HBs level or anti-HBc level.As for HBV M-positive specimens,anti-HBs level,anti-HBc level and HBsAg level had no correlation with HBV DNA,but anti-HBe level had negative correlation with HBV DNA and HBeAg level had positive correlation with HBV DNA. Conclusion Quantitative detection of HBV DNA level can reflect truly HBV replication,which is of guidence significance for infectivity evaluation and diagnosis and treatment of hepatitis B and efficacy observation.Al-though quantitative detection of HBV M has no significant value for HBV replication determination or infectivity evalu-ation,but it lays the foundation for management of hepatitis B data.
出处
《中国当代医药》
2014年第22期32-34,共3页
China Modern Medicine
