摘要
目的探讨血清抗环瓜氨酸肽抗体(抗-CCP)、碱性磷酸酶(ALP)、葡萄糖-6-磷酸异构酶(G6PI)和类风湿因子(RF)的检测在类风湿关节炎(RA)诊断中的意义。方法检测206例RA患者、68例其他自身免疫性疾病患者和48例健康体检者血清中RF、抗-CCP、ALP和G6PI的水平,同时测定红细胞沉降率(ESR);计算每个指标的敏感性和特异性并分析与RA诊断的关系。结果 RA组的各项血清指标水平明显高于其他两组(P<0.05),RF、抗-CCP和G6PI对RA的敏感性相近;特异性方面抗-CCP最高(94.8%),RF和G6PI相近;而敏感性和特异性相对较低的ALP在一定程度上也反映了RA的潜在性。结论同时检测RF、抗-CCP、G6PI和ALP可以提高RA早期诊断的准确性,减少漏诊,指导临床治疗。
Objective To investigate the detection of anti-cyclic citrullinated peptide（anti-CCP）antibody,alkaline phosphatase （ALP）,glucose-6-phosphate isomerase（G6PI）and rheumatoid factor（RF）in the diagnosis of rheumatoid arthritis（RA）.Methods Serum RF,anti-CCP body,ALP and G6PI were detected in 206 cases of RA,68 cases of other autoimmune diseases and 48 persons with the healthy physical examination,at the same time the erythrocyte sedimentation rate（ESR）was measured;the sensitivity and specificity of each indicator and the relationship between each index and RA′s diagnosis.Results The serum level of each index in the RA group was significantly higher than that in the other two groups（P〈0.05）.The sensitivity of RF,anti-CCP antibody and G6PI for diagnosing RA is similar;the specificity of anti-CCP body was highest（94.8%）,RF was similar to G6PI;ALP with rela-tively lower sensitivity and specificity also reflected the potential of RA to some extent.Conclusion The simultaneous detection of serum RF,anti-CCP body,G6PI and ALP can improve the accuracy of early diagnosis of RA,reduce the missed diagnosis and guide the clinical treatment.
出处
《国际检验医学杂志》
CAS
2014年第16期2187-2188,2196,共3页
International Journal of Laboratory Medicine
关键词
抗环瓜氨酸肽抗体
葡萄糖-6-磷酸异构酶
碱性磷酸酶
类风湿关节炎
anti-cyclic citrullinated peptide antibody
glucose-6-phosphate isomerase
alkaline phosphatase
rheumatoid arthritis
