摘要
目的系统评价粪肠球菌和难治性根尖周炎之间的相关性。方法计算机检索PubMed、ScienceDirect、EMbase、万方数据、CNKI、维普等数据库,全面收集有关难治性根尖周炎中粪肠球菌检出率的独立队列研究、病例-对照研究以及横断面研究,并追溯所获文献的参考文献,检索时限均从建库至2013年12月。按纳入和排除标准筛选文献、提取资料和评价质量后,采用Stata12.0软件进行统计分析。结果最终纳入18项研究,共728例难治性根尖周炎病例和748例对照病例。Meta分析结果显示,难治性根尖周炎中粪肠球菌的检出率明显高于对照病例,差异有统计学意义[OR=3.559,95%CI(1.696,7.470),P<0.05]。亚组分析和敏感性分析结果与上述结果一致。结论粪肠球菌与难治性根尖周炎间存在较为密切的关联,但具体机制仍待进一步研究。受纳入研究质量和数量所限,上述结论尚需今后开展更多高质量的研究加以验证和更新。
Objective To evaluate the correlation between Enterococcus faecalis and refractory periapical periodontitis. Methods Databases including PubMed, ScienceDirect, EMbase, WanFang Data, CNKI and VIP were searched from inception to December, 2013, so as to identify the independent cohort studies, case-control studies and cross-sectional studies. Moreover, the references of relevant studies were retrieved. According to the inclusion and exclusion criteria, the studies were screened, the data was extracted, and the methodological quality of the included studies was assessed. Then Meta- analysis was performed by Stata 12.0 software. Results A total of 18 studies were included, including 728 rafractory periapical periodontitis cases and 748 controlled cases. The results of Meta-analysis showed that the refractory periapical periodontitis group was more likely to have Enterococcus faecalis infection than the control group [OR=3.559, 95% CI（1.696,7.470）, P〈 0.05]. The same results were found in both sub-group and sensitivity analysis. Conclusions Enterococcus faecalis is closely related to refractory periapical periodontitis. However, detailed pathogenesis mechanism is still unknown. Due to the limited quality and quantity of the included studies, more high-quality studies are required to prove the analysis results above.
出处
《中华口腔医学研究杂志（电子版）》
CAS
2014年第4期5-9,共5页
Chinese Journal of Stomatological Research(Electronic Edition)
关键词
粪肠球菌
难治性根尖周炎
相关性
META分析
Enterococcus faecalis
Refractory periapical periodontitis
Correlation
Meta-analysis
