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冬凌草甲素靶向给药系统研究进展 被引量:1

Advances in Oridonin Targeted Drug Delivery System
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摘要 目的介绍冬凌草甲素靶向制剂的研究现状。方法综述近年来国内外相关研究,介绍靶向制剂靶向原理和特性、药动药效学研究进展,并对其可行性和前景进行分析。结果冬凌草甲素靶向制剂不仅可以提高冬凌草甲素的溶解度,而且提高了靶部位药物浓度,增强抗肿瘤效果、降低不良反应。结论开发更高靶向效率、安全、经济、多类型的给药系统是未来冬凌草甲素靶向制剂的研究焦点。 OBJECTIVE To introduce the progress on the research in oridonin targeted delivery. METHODS The researches of both domestic and abroad were reviewed in recent years. The targeting principal, efficiency, pharmacokinetics as well as pharmacodynamics were summarized. Its feasibility and prospect in drug delivery system was analyzed. RESULTS Oridonin targeted drug delivery system not only improves the solubility of oridonin, but also accumulates the drug at targeted sites, increases the anti-tumor activity and decreases toxicity. CONCLUSION The future research will focus on thedevelopment of kinds of oridonin targeted drug delivery system with high targeting efficiency, safety and economic.
出处 《中国现代应用药学》 CAS CSCD 2014年第8期1031-1036,共6页 Chinese Journal of Modern Applied Pharmacy
基金 浙江省卫生厅科研基金(2012KYA067) 浙江省自然科学基金(LQ12H30004)
关键词 冬凌草甲素 靶向 抗肿瘤 oridonin targeting anti-tumor
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