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RECK蛋白与微血管密度在子宫内膜癌组织中的表达及相关性 被引量:2

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摘要 目的:测定RECK蛋白及微血管密度(MVD)在子宫内膜癌组织中的表达,探讨RECK蛋白对MVD的影响及其在子宫内膜癌发生发展中的作用。方法:应用免疫组化S-P法检测50例子宫内膜癌组织标本,30例正常内膜组织中MVD及RECK蛋白的表达情况。结果:RECK蛋白在子宫内膜癌组织中阳性表达率为46.0%,正常子宫内膜组织中表达阳性率为80.0%,两组比较有显著差异(P<0.05)。MVD计数在正常内膜中为8.973 3±1.920 3,子宫内膜癌中为15.964 0±2.378 0,二者相比差异有显著性(P<0.05)。RECK蛋白的表达与MVD呈负相关(r=-0.747,P<0.05)。结论:子宫内膜癌组织中RECK蛋白呈低表达,与子宫内膜癌新生血管的形成有关,在子宫内膜癌发生、侵袭和转移中起重要作用。
出处 《实用医学杂志》 CAS 北大核心 2014年第17期2725-2727,共3页 The Journal of Practical Medicine
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