摘要
目的探讨经过干预的甲状腺功能减退症对自然流产的影响。方法对30只患有甲状腺功能减退症的大鼠进行左甲状腺素干预,合笼后观察其妊娠结局。用酶联免疫吸附实验(ELISA法)测定大鼠血清中游离甲状腺素(FT4)、促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPO-Ab)水平,进行阴道涂片,观察其动情周期,合笼后观察其妊娠结局。结果甲减组与甲减治疗组相比FT4水平较低,TSH偏高,TPO-Ab偏高,均有显著性差异(P<0.05);甲减治疗组与正常对照组相比三种激素水平无显著性差异(P>0.05);甲减治疗组与正常对照组仔鼠数量相比无显著性差异(P>0.05)。结论甲状腺功能减退症是导致自然流产的因素之一,可通过左甲状腺素治疗改善妊娠结局。
Objective To study the effect of hypothyroidism be treated with levothyroxine on spontaneous abortion. Method In 30 rats suffered from hypothyroidism treated with levothyroxine,observe their pregnancy outcomes. With Methods Enzyme-linked immunosorbent assay（ELISA）was adopted to measure rats serum FT4、TSH、TPO-Ab levels,doing the vaginal smears,finding their estrous cycle,observe their pregnancy outcomes. Giving the rats which suffered from hypothyroidism levothyroxine therapy,observe their pregnancy outcomes,and with Methods ELISA was adopted to measure rats serum FT4、TSH、TPO-Ab levels. Results To compare the hypothyroidism abortion group and the hypothyroidism abortion be treated group,FT4 levels are lower,TSH levels are higher,TPO-Ab levels are higher,there were significant differences between two groups in these three assays（P〈0.05）;To compare the hypothyroidism abortion be treated group and the normal control group,there was no significant difference in these three assays（P〉0.05）;To compare offspring numbers of the hypothyroidism abortion be treated group and the normal control group,there was no significant difference in these three assays（P〉0.05）.Conclusion Hypothyroidism is one of the factors causing spontaneous abortion,can improve the pregnancy outcomes by levothyroxine treatment.
出处
《基层医学论坛》
2014年第22期2885-2887,共3页
The Medical Forum
