摘要
目的:观察含左氧氟沙星的四联方案治疗幽门螺杆菌(H.pylori,Hp)的临床疗效及其安全性。方法:选取2013年1月-2014年1月到笔者所在医院消化科就诊的Hp感染患者104例,随机分为两组。治疗组采用左氧氟沙星、阿莫西林联合质子泵抑制剂和铋剂组成的四联疗法,对照组采用左氧氟沙星、阿莫西林联合质子泵抑制剂组成的三联疗法对Hp感染患者进行初治,两组疗程均为10 d。治疗结束4周后行13C-尿素酶呼气试验,判断Hp的根除情况,同时观察治疗过程中患者不良反应发生情况。结果:治疗组患者Hp根除率达96.3%,明显高于对照组的84.0%,差异有统计学意义(P<0.05)。两组患者均未见明显药物不良反应。结论:用含左氧氟沙星的四联方案治疗Hp感染疗效显著,且安全性高,值得临床推广使用。
Objective：To evaluate the clinical curative effect and safety of the levofloxacin-containing quadruple therapy as first-line therapy for eradication of Helicobacter pylori（H.pylori,Hp）.Method：104 patients with Hp infection in the Digestive Department of our hospital from January 2013 to January 2014 were randomly divided into two groups.The experimental group was treated with quadruple therapy containing Levofloxacin,Amoxicillin combined with proton pump inhibitor and bismuth.The control group was treated with triple therapy consist of Levofloxacin,Amoxicillin and proton pump inhibitor.The courses of both groups were all lasted 10 days.The eradication of Hp was assessed by 13C-urea breath test four weeks after the treatment of therapy,and the safety was also evaluated.Result：Hp eradication rate of the experiment group was 96.3%,much higher than the control group（84.0%）,the difference between two groups was significant（P〈0.05）.No serious adverse effects were found in two groups.Conclusion：Levofloxacin-containing quadruple therapy is effective in treating Hp infection. There is no adverse reaction,and it is worthy of clinical generalization apply.
出处
《中外医学研究》
2014年第24期19-20,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
