摘要
中年女性突发潮热是伴随更年期变化最常见和特异性的症状,而且也是最痛苦的症状之一,但其病理生理学机制尚未阐明。近年发现潮热的发生可能是多种因素作用的结果,其中下丘脑体温调定点范围变窄这一学说受到许多专家学者的认可。另外,雌激素降低影响中枢一些神经递质的改变对潮热的产生也有一定影响。有研究表明,潮热时去甲肾上腺素升高、5-羟色胺降低均会影响潮热时的体温调节。还有一些因素,如降钙素基因相关肽(calcitonin gene-related peptide,CGRP)、内啡肽以及一些社会心理方面的因素也与潮热的发生有关。现将更年期潮热机制的研究进展加以概括总结。
Hot flash is the most common and special symptom of menopause and also is one of the most painful symptoms. However,the mechanisms responsible for the pathogenesis of the hot flash are not completely understood. Recently , some researchers found that hot flash could be associated with kinds of factors .Among all possible reasons, hypothalamic temperature set point becoming narrow are widely accepted by most scholars . In addition, the low level of estrogen leads high level noradrenalin and low level 5-hydroxytryptamine which will impact thermoregulation. And also hot flash could be bound with calcitonin gene-related peptide ,beta-endorphin and other social psychological factors. Now we will summarize the current studies in the mechanisms of the hot flash.
出处
《国际妇产科学杂志》
CAS
2014年第4期466-468,共3页
Journal of International Obstetrics and Gynecology
基金
国家自然科学基金(81270666)
关键词
潮热
血管舒缩系统
去甲肾上腺素
血清素
体温调节
降钙素基因相关肽
Tidal fever
Vasomotor system
Norepinephrine
Serotonin
Body temperature regulation
Calcitonin gene-related peptide
