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氨磺必利与奋乃静治疗酒精所致精神障碍的研究 被引量:5

Clinical research on amisulpiride versus perphenazine in treatment of patients with mental disorder induced by alcohol
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摘要 目的比较氨磺必利与奋乃静治疗酒精所致精神障碍(MDIA)的临床疗效与安全性。方法将100例MDIA患者随机分成研究组和对照组,每组50例,分别使用氨磺必利与奋乃静治疗8周,用阳性与阴性综合征量表(PANSS)评定临床疗效,观察不良反应。结果在治疗后第4、8周末,研究组显效率高于对照组(χ2分别=4.86、5.83,P均<0.05);研究组和对照组治疗后第2、4、8周阳性症状、阴性症状、精神病理、总分均较基线明显下降(t分别=5.05、9.46、12.99、8.12、9.85、17.90、6.54、10.61、15.96、11.61、20.02、28.93、5.49、9.92、11.94、4.98、6.25、10.74、4.18、9.57、14.94、9.20、16.66、23.83,P均<0.05);研究组治疗后第2、4、8周的阴性症状、精神病理和总分均明显大于对照组(t分别=2.50、4.43、7.04、4.65、4.45、6.25、4.40、6.08、8.09,P均<0.05);研究组不良反应发生率和合并用药率低于对照组(χ2分别=6.62、11.76,P均<0.05)。结论氨磺必利治疗MDIA疗效确切,安全性高,优于奋乃静治疗。 Objective To compare the clinical efficacy and safety of amisulpiride and perphenazine in treatment of pa-tients with mental disorder induced by alcohol. Methods All 100 patients with mental disorder induced by alcohol were randomly assigned to study group and control group with 50 cases each. The patients were treated with amisupiride or per-phenazine respectively for 8 weeks. The clinical efficacy was evaluated by Positive and Negative Syndrome Scale (PANSS). The adverse reactions were observed. Results The rate of significant efficacy in the study group was significantly higher than that in the control group at the 4th, 8th weekend after treatment(χ2=4.86, 5.83, P〈0.05). The positive and negative syndrome, general spirit pathological factors and total scores of PANSS in the both groups after treatment were significantly lower than the baseline(t=5.05, 9.46, 12.99, 8.12, 9.85, 17.90, 6.54, 10.61, 15.96, 11.61, 20.02, 28.93, 5.49, 9.92, 11.94, 4.98, 6.25, 10.74, 4.18, 9.57, 14.94, 9.20, 16.66, 23.83, P〈0.05). In the 2nd,4th, 8th weekend after treat-ment, the negative syndrome, general spirit pathological factors and total scores of PANSS in study group was significantly greater than those in the control group(t=2.50, 4.43, 7.04, 4.65, 4.45, 6.25, 4.40, 6.08, 8.09, P〈0.05). The incidence of adverse effect and the rate of drug combination in the study group was significantly lower than those in the control group (χ2=6.62, 11.76, P〈0.05). Conclusion Amisulpiride is rather effective and safe in treatment of patients with mental disorder induced by alcohol. It is better than perphenazine.
出处 《全科医学临床与教育》 2014年第4期389-391,404,共4页 Clinical Education of General Practice
关键词 酒精所致精神障碍 氨磺必利 疗效 安全性 mental disorder induced by alcohol amisupiride efficacy safety
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  • 1中华医学会精神科分会.中国精神障碍分类与诊断标准第3版(CCMD-3)[M].济南:山东科学技术出版社.2011:106-107.
  • 2黄宁波,吴彦霞.饮酒与酒精性肝病的病例对照研究[J].医药与保健:下旬版,2009,12(3):33-35.
  • 3Rachdaoui N, Sarkar DK. Effects of alcohol on the endocrine system [ J]. Endocrinol Metab Clin North Am,2013,42 ( 3 ) :593 - 615.
  • 4Thorsell A, Tapocik JD, Liu K, et al. A novel brain penetrant NPS receptor antagonist, NCGC00185684, blocks alcohol-induced ERK- phosphorylation in the central amygdala and decreases operant alcohol self-administration in rats [ J ]. J Neurosci, 2013, 33 (24) :10132.
  • 5Mandal N, Singh OP, Sen S. Extrapyramidal side effects with low doses of amisulpride [ J ]. Indian J Psychiatry, 2014,56 ( 2 ) : 197.
  • 6Paquot N, De Flines J, Scheen AJ. Alcoholism, an addiction leading to multiple somatic complications [ J ]. Rev Med Liege, 2013,68 ( 5/ 6 ) :272 - 280.
  • 7Michalak S, Micha owska-Wender G, Adamcewicz G, et al. Erythrocyte transketolase activity in patients with diabetic and alcoholicneuropathies[ J]. Folia Neuropatho1,2013,51 ( 3 ) :222 - 226.
  • 8Nuss P, Tessier C. Antipsychotic medication, functional outcome and quality of life inschizophrenia: focus on amisulpride [ J ]. Curr Med Res Opin ,2010,26 (4) :787 - 801.
  • 9Goswami K, Saddichha S, Chaturvedi SK. Amisulpride treatment of somatoform disorders :not just chronic fatigue[ J]. Am J Ther,2014, 21(2) :e48 -e49.
  • 10吴强,连卓,李艳红.酒精所致精神障碍230例临床分析[J].中国药物依赖性杂志,2010,19(3):200-202. 被引量:12

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