摘要
目的测定RA患者血清中脂联素水平，探讨脂联素在RA患者中的临床意义。方法用ELISA法检测53例RA及31名健康对照组血清脂联素水平，分析脂联素与临床及实验室指标的相关性。统计学方法采用t检验、单因素方差分析和Spearman相关分析。结果RA组血清脂联素水平明显高于健康对照组[（12±8）txg／ml和（8±4）04／ml，t=3．694，P=0．0023。RA组脂联素与RF、抗CCP抗体滴度呈负相关（r=-0．301，r=-0．290，P均＜0．05），与球蛋白、IgA、IgM呈正相关（r=0．492，r=0．431，r=0．485，P均＜0．05），与ESR、CRP、DAS28、体质量指数（BMI）、抗链球菌溶血素（ASO）、IgG、肝肾功能、Tc、TG、补体、凝血酶原时间（PT）系列等无相关性（JP均＞O．05）。病程10～15年的RA患者脂联素与BMI呈负相关（r=-0．197，P＜0．05）。结论脂联素可能与RA的自身抗体产生有关，参与RA炎性活动过程。
Objective To study the expression of adiponeetin in the peripheral blood of patients with rheumatoid arthritis （RA）, and discuss its role in the pathogenesis of RA. Methods Fifty-three patients with RA and 31 healthy controls were enrolled in the study. The level of adiponectin in the peripheral blood were detected using enzyme-linked immunosorbent assay （ELISA） method and the relation with clinical and laboratory parameters were analyzed. The stastistical analysis was carried out with independent t-test, one-way ANOVA and Spearman correlation analysis. Results The level of the adiponectin in rheumatoid arthritis patients [ （ 12±8 ） μg/ml ] was higher than control group [ （8±4）μg/ml], with statistically significant difference （t=3.694, P=O.002）. The level of adiponectin of the experimental group was negatively correlated with rheumatoid factor （RF）, anti-cyclic centrullinated peptides （anti-CCP） （r=-0.301, r=-0.290, P〈O.05 ） and positively correlated with the levels of globulin （GLO）, IgA and IgM （r=0.492, r=0.431, r=0.485, P〈O.05）, while no significant correlation （P〉0.05） with erythrocyte sedimentation rate （ESR）, C reactive protein （CRP）, disease activity score in 28 joints （DAS28）, Body mass index （BMI）, anti streptolysin O （ASO）, IgG, liver and kidney function, triglyceride （TG） and cholesterol （TC）, C3, C4 levels and prothrombin time （PT） series. The level of adiponectin of the whole experimental group was not significantly correlated with BMI （r=0.142, P〉0.05）, but negatively correlated with BMI （r=0.197, P〈0.05） in patients with 10-15 years courses of disease. Conclusion Related to RF and CCP, adiponeetin may be involved in the pathogenesis of chronic inflammation of RA.
出处
《中华风湿病学杂志》
CAS
CSCD
北大核心
2014年第8期549-551,共3页
Chinese Journal of Rheumatology
关键词
关节炎
类风湿
自身抗体
脂联素
Arthritis, rheumatoid
Autoantibodies
Adiponectin
