摘要
目的观察桂枝芍药知母加味汤联合常规疗法治疗类风湿关节炎的临床疗效。方法将91例类风湿关节炎患者随机分为治疗组(46例)与对照组(45例)。对照组采用常规疗法治疗,治疗组同时加用桂枝芍药知母加味汤。两组疗程均为4周,观察临床疗效及同型半胱氨酸(Hcy)、血沉(ESR)、C反应蛋白(CRP)的变化情况。结果 1治疗组、对照组总有效率分别为89.13%和73.33%;组间临床疗效比较,差异有统计学意义(P<0.05)。2治疗前后组内比较,两组Hcy、CRP、ESR水平差异均有统计学意义(P<0.05);组间治疗后比较,Hcy、CRP、ESR水平及其变化差值差异有统计学意义,治疗组优于对照组(P<0.05)。结论桂枝芍药知母加味汤联合常规疗法治疗类风湿关节炎的疗效满意,可显著缓解患者的临床症状,同时还可改善其高同型半胱氨酸血症,从而可能延缓类风湿关节炎所致心血管进一步损害的进程。
Objective To observe the clinical efficacy of ＂Guizhi Shaoyao Zhimu Decoction＂and conventional therapy in treating rheumatoid arthritis（ RA）.Methods Ninety-one cases with RA were randomized into treatment group and control group. Control group in which 45 cases were treated by conventional therapy and treatment group in which 46 cases were added with＂Guizhi Shaoyao Zhimu Decoction＂,with the course of 4 weeks. We observed the clinical efficacy,and changes of Hcy,ESR and CRP. Results 1 The total effective rate was 89. 13% in the treatment group and 73. 33% in the control group,with a difference between the two groups（P〈0.05）. 2 In both groups,there were significant differences in the levels of Hcy,CRP and ESR between before and after treatment（P〈0.05）; after treatment,with significant differences in the levels of Hcy,CRP and ESR between the two groups（P〈0.05）. Conclusion Combined＂Guizhi Shaoyao Zhimu Decoction＂and conventional therapy has positive effect on RA. It can retard the process of further damage caused by RA through relieving clinical symptoms and improving homocysteine.
出处
《上海中医药杂志》
2014年第8期46-48,共3页
Shanghai Journal of Traditional Chinese Medicine
基金
陕西省西安市科技局重点学科专科临床技术研究项目[SF09023(2)]
关键词
类风湿关节炎
心血管损害
桂枝芍药知母汤
同型半胱氨酸
C反应蛋白
rheumatoid arthritis（RA）
cardiovascular disease
＂Guizhi Shaoyao Zhimu Decoction＂
homocysteine
C-reactive protein
