摘要
转录调节因子p53作为一种抑癌基因,可诱导细胞生长阻滞、凋亡、分化以及DNA修复。突变型p53丧失了野生型p53的正常功能,能促进细胞增殖转化而且具有致癌作用。TGF-β超家族信号通路广泛参与胚胎发育,细胞增殖、分化、迁移和凋亡,创伤修复。P53与TGF-β通路之间有着广泛的联系,同时二者在肿瘤等疾病中都有着重大的作用。文章研究了p53与TGF-β通路之间的联系以及在某些生物学中的功能。
The tumor suppressor gene p53 is a transcription factor that mediates several cellular processes including growth arrest, apoptosis ,differentiation and DNA damage repair. At the same time, mutant p53 generally subverts TGF-[3 responses, diminishing transcriptional activation of key TGF-β target genes. Mutant p53 can also interact with Smads, which enables complex formation with the p53 family member p63 and blocks p63-mediated activation of metastasis suppressing genes to promote tumour progression. TGF-β is an important regulator for human, which plays important roles in embryonic development, cell growth, differentiation, migration and apoptosis. P53 has a close correlation with TGF-β signalling pathway . Wild-type p53 and TGF-β are key tumour suppressors regulate an array of cellular responses. They play important roles in the occurrence and development of carcinoma. Accurately under- standing the regulatory relationship between p53 and TGF-β signalling and the potential roles it plays in some biological function ,will help us recognize the process of some diseases development, and eventually help us to cure them.
出处
《药物生物技术》
CAS
2014年第4期359-362,共4页
Pharmaceutical Biotechnology
基金
国家自然科学基金资助项目(No.30873198)
