摘要
胆碱能抗炎通路的分子机制是迷走神经受刺激,大量乙酰胆碱释放,并与免疫细胞表面的特异受体结合,从而发挥一系列抗炎效应。乙酰胆碱受体分为毒蕈碱(M)和烟碱(N)受体,其中N受体作为神经递质受体大家族之一,其α7亚单位是胆碱能抗炎通路下调细胞因子合成的关键受体亚单位,也是发挥抗炎效应的主要受体。胃肠道同样分布有胆碱能受体,研究其在胃肠疾病及损伤方面的作用和机制将为消化系病的药物开发和防治带来新的契机。
The molecular mechanisms of the cholinergic anti-inflammatory pathway is ： the stimulated vagus nerve leads to the release of a large number of acetylcholine（Ach） ,which combined with the specific receptors on the surface of the immune cells, so as to play a series of anti-inflammatory effects. Ach receptors are divided into muscarinic receptor（M） and nicotinc receptor（N）. N receptor as one of the large family of receptors, its α7 subunit is the key receptor subunit in the synthesis of down-regulating cytokines in cholinergic anti-inflammatory pathway, and is the main receptor in playing the anti-inflammatory effects. There are cholinergic receptors in gastrointestinal tract, the research on the effects and mechanisms of cholinergic anti-inflammatory pathway will bring a new chance in the drug development and prevention of digestive diseases and injuries.
出处
《医学综述》
2014年第16期2919-2921,共3页
Medical Recapitulate
关键词
胆碱能抗炎通路
胆碱能受体
消化系疾病与损伤
抗炎作用
Cholinergic anti-inflammatory pathway
Acetylcholine receptor
Digestive diseases and injuries ： Anti-inflammatory effect
