摘要
目的了解安国市孕妇弓形虫感染状况及其对妊娠结局的影响。方法采用酶联免疫吸附试验(ELISA)检测3 891例孕妇外周血中弓形虫IgM和IgG抗体。根据检测结果分为急性感染组、既往感染组、活动性感染组,随机抽取200名检测结果为阴性的无弓形虫感染的孕妇作为对照组,对4组孕妇进行随访,观察比较其妊娠结局。结果在3 891例被调查的孕妇中,弓形虫感染353例,其中急性感染51例、既往感染197例、活动性感染105例,总感染率为9.07%(353/3 891);对应各感染组及对照组不良妊娠结局发生率分别为17.65%(9/51)、2.03%(4/197)、6.67%(7/105)和1.50%(3/200)。急性感染组和活动性感染组不良妊娠结局发生率与对照组比较,差异有统计学意义(P<0.05);既往感染组不良妊娠结局发生率与对照组比较,差异无统计学意义(P>0.05)。郊区孕妇弓形虫阳性率高于市区妇女,农民阳性率高于工人、干部和其他职业者,有动物密切接触史和喜食生食者阳性率较高,差异均有统计学意义(P<0.05)。结论急性感染和活动性感染与孕妇不良妊娠结局密切相关。建议孕妇加强弓形虫筛查工作,以便及早诊治;加强健康教育,改变不良生活习惯;加强水源、粪便等卫生管理。
Objective To investigate the Toxoplasma gondii infection status and the impact on pregnancy outcomes.Methods Toxoplasma IgM and IgG antibody in the peripheral blood in 3 891 cases of pregnant woman were detected by using enzyme-linked immunosorbent assay（ELISA）. Infected ones were divided into acute infection group, previous infection group, active infection group according to the test results. 200 pregnant women without Toxoplasma gondii infection were randomly chosen as control group, and pregnancy outcome of four groups were followed up and compared. Results There were 353 cases infected with Toxoplasma gondii in 3 891 pregnant women, with an infection of 9.07%（353 / 3 891）. In which,51 cases were diagnosed as acute infection, 197 were previous cases, and the other 105 were active infection. The incidences of adverse pregnancy outcome in the above 3 groups and the control groups were 17.65%（9 / 51）, 2.03%（4 / 197）, 6.67%（7 /105） and 1.50%（3 / 200）, respectively. The incidences of adverse pregnancy outcome in acute infection group and active infection group were both higher than those in the control group; the differences were statistically significant（P〈0.05）,while there were no significant difference between the previous infection group and the control group（P〈0.05）. The rate among women living in the suburb was higher than that in downtown area（P〈0.01）; the rate among women who contacting animals and eating uncooked food was higher than that of control（P〈0.01）. Conclusion Acute and active infection are closely associated with the occurrence of adverse pregnancy outcome in early pregnant women. Toxoplasma IgM antibody should be included in the routine inspection items of pre-pregnancy medical examination for child-bearing age women.
出处
《热带医学杂志》
CAS
2014年第8期1057-1059,共3页
Journal of Tropical Medicine
关键词
弓形虫
孕期妇女
妊娠结局
Toxoplasma gondii
pregnant women
adverse pregnancy outcome
