摘要
目的:探讨粘液炎症性纤维母细胞肉瘤的病理形态学特征、免疫学表型及鉴别诊断。方法:对1例发生于右前臂内侧的粘液炎症性纤维母细胞肉瘤进行形态学观察及免疫组化标记。结果:肿瘤组织由炎症样区、粘液样区及纤维化区组成。最明显的特征是,有明显异型的肥胖的梭形细胞、神经节细胞样细胞、畸形的R-S样细胞或病毒样细胞,还可见到脂母细胞样细胞。免疫组化示肿瘤细胞Vimentin、Bcl-2、CD99和CD68阳性,CD34灶性阳性,CD30、CD15、EMA、CK、SMA、desmin、p53、S-100和ALK1均为阴性。结论:粘液炎症性纤维母细胞肉瘤是一种罕见的低度恶性粘液纤维母细胞性肿瘤,最常发生于肢端。肿瘤细胞由变异的纤维母细胞衍化而来,具有独特的病理学特征。由于肿瘤在局部呈侵袭性生长,复发率高,推荐局部扩大切除治疗。
Objective： To study the clinical pathological features, immunohistochemi-eal characteristics and differential diagnosis of myxoinflammatory fibroblastie sarcoma（MIFS）. Methods：A ease of MIFS in right forearm was studied by light microscopy and immunohistochemistry. Results： Microscopically, the turnout was characterized by a dense inflammatory infiltrate merging with hyalineand myxoid zones invariable proportions. In the turnout, spindled cells, ganglion like or R-S like cells, and lipoblast like cells were seen. Immunohistochemieally, the expression of vimentin, Bel-2, CD99 and CD68 was present in the spindle cells,CD34 was present focusly,but all were negative for CD30,CD15 ,EMA,CK,SMA,desmin,p53 ,S-100 and ALKI. Conclusion ：MIFS is an extremely rare tumor of modified fibreblast cells, with low grade malignancy. It most commonly occurs in the distal extremities. The tumor cells may derive from modified fibroblast and has its specific pathobiology feature. As the tumor behaviors aggressively with a high rate of local recurrence,complete excision is recommended.
出处
《农垦医学》
2013年第5期385-388,共4页
Journal of Nongken Medicine
关键词
粘液炎症性纤维母细胞肉瘤
临床病理学
诊断
鉴别诊断
Myxoinfammatory fiboroblastic sarcoma
Clinicopathology
Diagnosis
differential diagnosis
