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艾荆香汤剂对特异性皮炎小鼠血清IgE和TGF-β表达的影响 被引量:2

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摘要 目的:探讨艾荆香汤剂对特异性皮炎(AD)小鼠模型皮肤炎症症状和血清中免疫球蛋白lgE和转化生长因子-β(TGF-β)表达的影响。方法:通过外用2,4-二硝基氟苯(DNFB)丙酮制备实验特异性皮炎小鼠模型,小鼠随机分为正常组(n=10)、模型组(n=10)和艾荆香汤剂组(n=10)。造模后9d各组皮炎症状打分,ELISA检测血清lgE和TGF-β表达。结果:与正常组比较,模型组和艾荆香汤剂组皮炎症状显著,lgE和TGF-β表达显著增高(P<0.01)。与模型组比较,艾荆香汤剂组皮炎症状显著减轻,lgE和TGF-β表达显著降低(P<0.01)。结论:艾荆香汤剂可通过下调特异性皮炎血清lgE和TGF-β等细胞因子的表达,改善特异性皮炎临床症状。
出处 《中医药临床杂志》 2014年第8期844-845,共2页 Clinical Journal of Traditional Chinese Medicine
基金 黑龙江省教育厅科学技术研究项目(编号12531743)
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